The long-term outcome of 1390 children with acute lymphoblastic leukemia (ALL), treated in
two successive clinical trials (Taiwan Pediatric Oncology Group (TPOG)-ALL-97 and TPOG …

BACKGROUND It is believed that Ras mutations drive the proliferation of leukemic cells. The
objective of this study was to investigate the association of Ras mutations with childhood …

Epidemiologic studies of childhood leukemia have made limited use of tumor genetic
characteristics, which may be related to disease etiology. We characterized the cytogenetics …

ETV6 is an important hematopoietic regulatory factor and ETV6 gene rearrangement is
involved in a wide variety of hematological malignancies. In this study, we sought to …

Background We aimed to investigate the frequencies and the association with
genetic/cytogenetic abnormalities as well as prognostic relevance of RAS pathway …

Objective: Based on the immunophenotype, acute lymphoblastic leukemia (ALL) can be
categorized into B-cell or T-cell lineages. B-cell precursor ALL (BCP-ALL) cases show …

This study was conducted to determine the frequency of the most common fusion genes in
Mexican pediatric patients with acute lymphoblastic leukemia (ALL). Molecular analysis …

In 1963, Jean Bernard, a French hematologist, opened a new chapter in hematology called
geographic hematology ('Hématologie Géographique'). He distinguished two research …

Abstract Background Both ETV6–RUNX1 (TEL–AML1) fusion and hyperdiploidy (> 50
chromosomes) in transformed lymphoblasts are favorable genetic features in childhood …

A total of 69 patients of B lineage ALL, 35 children (32 males, 3 females) and 34 young
adults (27 males, 7 females) were studied by multiplex RT‐PCR to determine the relative …