Synaptic and circuit functions of multitransmitter neurons in the mammalian brain

ML Wallace, BL Sabatini - Neuron, 2023 - cell.com
Neurons in the mammalian brain are not limited to releasing a single neurotransmitter but
often release multiple neurotransmitters onto postsynaptic cells. Here, we review recent …

[HTML][HTML] Cell type specificity for circuit output in the midbrain dopaminergic system

S Blaess, S Krabbe - Current opinion in neurobiology, 2023 - Elsevier
Midbrain dopaminergic neurons are a relatively small group of neurons in the mammalian
brain controlling a wide range of behaviors. In recent years, increasingly sophisticated …

[HTML][HTML] Alterations in neurotransmitter co-release in Parkinson's disease

K Barcomb, CP Ford - Experimental Neurology, 2023 - Elsevier
Parkinson's disease is a neurological disorder characterized by degeneration of midbrain
dopamine neurons, which results in numerous adaptations in basal ganglia circuits …

Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release

SM Warlow, SM Singhal, NG Hollon, L Faget… - Neuron, 2024 - cell.com
Ventral tegmental area (VTA) projections to the nucleus accumbens (NAc) drive reward-
related motivation. Although dopamine neurons are predominant, a substantial …

[HTML][HTML] Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta

WS Conrad, L Oriol, L Faget, TS Hnasko - bioRxiv, 2024 - ncbi.nlm.nih.gov
Most studies on the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc)
have focused on dopamine neurons and their role in processes such as motivation …

65 years of research on dopamine's role in classical fear conditioning and extinction: A systematic review

R Hamati, J Ahrens, C Shvetz… - European Journal of …, 2024 - Wiley Online Library
Dopamine, a catecholamine neurotransmitter, has historically been associated with the
encoding of reward, whereas its role in aversion has received less attention. Here, we …

[HTML][HTML] Emotion in action: when emotions meet motor circuits

A Braine, F Georges - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
The brain is a remarkably complex organ responsible for a wide range of functions,
including the modulation of emotional states and movement. Neuronal circuits are believed …

[HTML][HTML] Anterograde trans-neuronal labeling of striatal interneurons in relation to dopamine neurons in the substantia nigra pars compacta

F Karube, Y Yang, K Kobayashi… - Frontiers in …, 2024 - frontiersin.org
Recent advances in neural tracing have unveiled numerous neural circuits characterized by
brain region and cell type specificity, illuminating the underpinnings of specific functions and …

[HTML][HTML] Prevalent co-release of glutamate and GABA throughout the mouse brain

CC Ceballos, L Ma, M Qin, H Zhong - bioRxiv, 2024 - ncbi.nlm.nih.gov
Several neuronal populations in the brain transmit both the excitatory and inhibitory
neurotransmitters, glutamate, and GABA, to downstream neurons. However, it remains …

Dopamine enhances multisensory responses in the dorsomedial striatum

M Sáez, J Alegre-Cortés, NA Morgenstern… - bioRxiv, 2023 - biorxiv.org
The brain operates with simultaneous different sensory modalities in order to engage
adaptive responses. However, the question of how (and where) multisensory information is …