Primary open-angle glaucoma

RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

The trabecular meshwork: Structure, function and clinical implications. A review of the literature

J Buffault, A Labbé, P Hamard… - Journal francais d' …, 2020 - Elsevier
Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased
intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle …

Role of fibronectin in primary open angle glaucoma

JA Faralli, MS Filla, DM Peters - Cells, 2019 - mdpi.com
Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd
most common cause of irreversible vision loss in the United States. Nearly 67 million people …

Natural cholinesterase inhibitors from marine organisms

LWK Moodie, K Sepčić, T Turk, R Frangež… - Natural product …, 2019 - pubs.rsc.org
Covering: Published between 1974 up to 2018 Inhibition of cholinesterases is a common
approach for the management of several disease states. Most notably, cholinesterase …

[HTML][HTML] Extracellular matrix stiffness and TGFβ2 regulate YAP/TAZ activity in human trabecular meshwork cells

H Li, VK Raghunathan, WD Stamer… - Frontiers in Cell and …, 2022 - frontiersin.org
Primary open-angle glaucoma progression is associated with increased human trabecular
meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in …

Minimally invasive glaucoma surgery as primary stand‐alone surgery for glaucoma

NM Kerr, J Wang, K Barton - Clinical & experimental …, 2017 - Wiley Online Library
Recently, many new devices and procedures have been developed to lower intraocular
pressure in a less invasive and purportedly safer manner than traditional glaucoma surgery …

Significance of optineurin mutations in glaucoma and other diseases

Y Minegishi, M Nakayama, D Iejima, K Kawase… - Progress in retinal and …, 2016 - Elsevier
Glaucoma is one of the leading causes of bilateral blindness, affecting nearly 57 million
people worldwide. Glaucoma is characterized by a progressive loss of retinal ganglion cells …

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure

H Choquet, KK Thai, J Yin, TJ Hoffmann… - Nature …, 2017 - nature.com
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of
blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci …

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

G Li, C Lee, AT Read, K Wang, J Ha, M Kuhn, I Navarro… - Elife, 2021 - elifesciences.org
Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening
adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the …

Understanding drivers of ocular fibrosis: current and future therapeutic perspectives

F Mallone, R Costi, M Marenco, R Plateroti… - International journal of …, 2021 - mdpi.com
Ocular fibrosis leads to severe visual impairment and blindness worldwide, being a major
area of unmet need in ophthalmology and medicine. To date, the only available treatments …