Biomarkers are molecular indicators of a biological status, and as biochemical species can
be assayed to evaluate the presence of cancer and therapeutic interventions. Through a …

Abstract The development of Bcr‐Abl tyrosine kinase inhibitors has dramatically changed
the prognosis of patients with newly diagnosed chronic myeloid leukemia (CML). Standard …

To support pharmacokinetic‐guided dosing in individual patients, a fast and accurate
method for simultaneous determination of anticancer tyrosine kinase inhibitors (TKIs) …

Two types of endocrine disease are discussed: Thyroid and adrenal. Serum levels of T4 (or,
better, free T4) and thyroid-stimulating hormone can be used to diagnose primary or …

Therapeutics harnessing the power of personalized medicine have the potential to
revolutionize healthcare. Companion diagnostics are critical to this goal and are …

Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-
derived growth factor receptor kinases. Methotrexate is an antimetabolite and antifolate …

Leukemia merupakan penyakit keganasan sel darah yang berasal dari sumsum tulang
ditandai oleh proliferasi sel-sel darah putih, dengan manifestasi adanya sel-sel abnormal …

This chapter summarizes the significance and molecular diagnostic detection of genetic
abnormalities commonly associated with hematolymphoid neoplasms. Methodologic …

The Cepheid Xpert BCR-ABL Monitor assay (Cepheid, USA) is a CE marked in vitro
diagnostic (IVD) assay designed for monitoring the levels of p210 BCR-ABL fusion …

A 43-year-old man presented with a two-year history of HIV infection, complicated with
cytomegaloviral retinitis and oral thrush. He initially noticed a swelling in his left axilla. CT …