Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in
tumour progression from malignant transformation to metastasis and immune evasion. One …

Antibodies play a critical role in linking the adaptive immune response to the innate immune
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …

Healthy immune responses require efficient protection without excessive inflammation.
Recent discoveries on the degree of fucosylation of a human N-linked glycan at a conserved …

Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …

The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human
IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly …

Over the last decades, cancer immunotherapies such as checkpoint blockade and adoptive
T cell transfer have been a game changer in many aspects and have improved the treatment …

Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past
30 years. Clinical success rates of antibodies have exceeded expectations, resulting in …

Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a
long-established, substantial role in the safety and pharmacokinetic properties of this …

Ensuring consistent high yields and product quality are key challenges in biomanufacturing.
Even minor deviations in critical process parameters (CPPs) such as media and feed …