Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

Immunomodulation of tumor‐associated macrophages (TAMs) into tumor‐inhibiting M1‐like
phenotype is a promising but challenging strategy. Cleverly, tumor cells overexpress CD47 …

Extensive clinical and experimental evidence suggests that macrophages play a crucial role
in cancer immunotherapy. Cluster of differentiation (CD) 47, which is found on both healthy …

Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

Toll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells
and various tumor cells. TLR7/8 are located in the intracellular endosomes, participate in …

In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most
abundant immune cells, which act as a key regulator in tumorigenesis and progression …

Abstract Background BCMA CAR-T is highly effective for relapsed/refractory multiple
myeloma (R/R-MM) and significantly improves the survival of patients. However, the short …

Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to
ICIs causes only subsets of patients to achieve durable responses due to the complex tumor …

Abstract Cluster of differentiation 47 (CD47) is a transmembrane protein that is ubiquitously
found on the surface of many cells in the body and uniquely overexpressed by both solid …