Macrophages derived from human monocytic leukemia THP-1 cell line are often used as the
alternative of human primary macrophage. However, the polarization method of THP-1 to …

CD36 is a membrane protein with wide distribution in the human body, is enriched in the
monocyte-macrophage system and endothelial cells, and is involved in the cellular uptake of …

Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic
malignancies, but its application to solid tumors has been challenging,,–. Given the unique …

Cellular cross-talk within the tumor microenvironment (TME) by exosomes is known to
promote tumor progression. Tumor promoting macrophages with an M2 phenotype are …

Human peripheral-blood monocytes are used as an established in vitro system for
generating macrophages. For several reasons, monocytic cell lines such as THP-1 have …

The three-dimensional arrangement of the human genome comprises a complex network of
structural and regulatory chromatin loops important for coordinating changes in transcription …

Lipopolysaccharide (LPS), the major outer surface membrane component of Gram-negative
bacteria, is one of the main etiological factors in the pathogenesis of several lung diseases …

Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most
studied group of compounds obtained from Cannabis sativa because of their several …

In vitro models of differing macrophage functions are useful since human monocyte–derived
macrophages are short–lived, finite and vary from donor to donor. Published protocols using …

In situ tissue engineering is a technology in which non-cellular biomaterial scaffolds are
implanted in order to induce local regeneration of replaced or damaged tissues. Degradable …