Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …

Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug
targets because they can produce fewer on-target side effects, improved selectivity, and …

Urotensin II receptor (UT) modulators that differentiate the effects of the endogenous cyclic
peptide ligands urotensin II (UII) and urotensin II-related peptide (URP) offer potential for …

Urotensin II (UII) is a polypeptide molecule with neurohormone-like activity. It has been
confirmed that UII is widely distributed in numerous organs of different animal species from …

Highlights•Urotensin II is a cyclic undecapeptide involved in cardiovascular
regulation.•Pseudo-irreversible binding to UT receptor could explain urotensin II low …

Aim SB-710411 is a rat selective urotensin-II (U-II) receptor antagonist, which can block U-II-
induced contraction of the aorta and inhibit U-II-induced myocardial fibrosis in rats. However …

The urotensinergic system was previously considered as being linked to numerous
physiopathological states, including atherosclerosis, heart failure, hypertension, pre …

Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is
involved in the pathophysiology of many disorders. For example, it plays an important role in …

Benzotriazepin-2-ones were designed to mimic the suggested bioactive γ-turn conformation
of the Bip-Lys-Tyr tripeptide in Urocontrin ([Bip4] URP), which modulates the urotensin II …

A proof-of-concept library of pyrrolodiazepinone small molecules was designed based on
the Bip-Lys-Tyr motif found in a recently described modulator of the urotensinergic system …