[HTML][HTML] Inflammatory Response in the Pathogenesis and Treatment of Hepatocellular Carcinoma: A Double-Edged Weapon

L Galasso, L Cerrito, V Maccauro, F Termite… - International Journal of …, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) is the most frequent among primary liver tumors (90%) and
one of the main causes of cancer-related death. It develops usually in a chronically inflamed …

Immune signature and therapeutic approach of natural killer cell in chronic liver disease and hepatocellular carcinoma

SK Shin, S Oh, SK Chun, MJ Ahn… - Journal of …, 2024 - Wiley Online Library
Natural killer (NK) cells are one of the key members of innate immunity that predominantly
reside in the liver, potentiating immune responses against viral infections or malignant …

Multiomics profiling of buffy coat and plasma unveils etiology-specific signatures in hepatocellular carcinoma

J Hong, JW Eun, GO Baek, JY Cheong, S Park… - Clinical and Molecular …, 2024 - e-cmh.org
Methods We generated whole-transcriptome sequencing (WTS) and targeted proteome data
from buffy coat and plasma samples from HCC patients. By integrating etiological …

An integrated investigation of sulfotransferases (SULTs) in hepatocellular carcinoma and identification of the role of SULT2A1 on stemness

H Peng, K Feng, W Jia, Y Li, Q Lv, Y Zhang - Apoptosis, 2024 - Springer
The cytosolic sulfotransferases (SULTs) are phase II conjugating enzymes, which are widely
expressed in the liver and mainly mediate the sulfation of numerous xenobiotics and …

Limited Generalizability of Retrospective Single-Center Cohort Study in Comparison to Multicenter Cohort Study on Prognosis of Hepatocellular Carcinoma

YR Kim, SW Chung, MJ Kim, WM Choi… - Journal of …, 2024 - Taylor & Francis
Introduction We aimed to evaluate the generalizability of retrospective single-center cohort
studies on prognosis of hepatocellular carcinoma (HCC) by comparing overall survival (OS) …

[HTML][HTML] Advances in chemotherapy-resistant hepatocellular carcinoma

S Liu, Q Li, Y Li, J Sheng - Frontiers in Medicine, 2023 - frontiersin.org
Primary liver cancer, including hepatocellular carcinoma and cholangiocarcinoma, has a
poor prognosis. According to the American Cancer Society statistics, the 5-year survival rate …

[HTML][HTML] Exploring the prognostic value of ultra-low-pass whole-genome sequencing of circulating tumor DNA in hepatocellular carcinoma

JE Han, HJ Cho - Clinical and Molecular Hepatology, 2024 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and a
leading cause of cancer-related mortality worldwide. Many cases of HCC are diagnosed at …

[HTML][HTML] Comparison between Nivolumab and Regorafenib as Second-line Systemic Therapies after Sorafenib Failure in Patients with Hepatocellular Carcinoma

HJ Lee, JS Lee, H So, JK Yoon, JY Choi, HW Lee… - Yonsei Medical …, 2024 - ymj.or.kr
Purpose Nivolumab and regorafenib are second-line therapies for patients with advanced
hepatocellular carcinoma (HCC). We aimed to compare the effectiveness of nivolumab and …

Role of transarterial chemoembolization for hepatocellular carcinoma with extrahepatic metastases in the era of advancing systemic therapy

BG Song, MJ Goh, W Kang, DH Sinn, GY Gwak… - Journal of Liver …, 2024 - e-jlc.org
Methods This study analyzed 248 consecutive patients with HCC and EHM (median age
58.5 years, 83.5% male, and 88.7% Child-Pugh A) who received TACE or systemic therapy …

[HTML][HTML] Systemic Chemotherapy with Combination of Immune Checkpoint Inhibitor and Tyrosine Kinase Inhibitor in Unresectable Hepatocellular Carcinoma

혜연전 - The Korean Journal of Gastroenterology - synapse.koreamed.org
최근 5 년 동안 진행성 간암에서 PD-1/PD-L1 경로를 표적으로 하는 면역관문억제제 (Immune
check point inhibitor, ICI) 가 새로운 치료 약제로서 대두되었다. 하지만 현재까지 진행성 …