New and Old Key Players in Liver Cancer
ÁM Cuesta, N Palao, P Bragado… - International Journal of …, 2023 - mdpi.com
Liver cancer represents a major health problem worldwide with growing incidence and high
mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely …
mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely …
Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways
H Postwala, Y Shah, PS Parekh, MR Chorawala - Medical Oncology, 2023 - Springer
Colorectal cancer (CRC) is a complex disease characterized by genetic and epigenetic
alterations, playing a crucial role in its development and progression. This review aims to …
alterations, playing a crucial role in its development and progression. This review aims to …
FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression
H Xu, Y Yin, Y Li, N Shi, W Xie, W Luo, L Wang, B Zhu… - Iscience, 2024 - cell.com
In nasopharyngeal carcinoma (NPC), the TGF-β/Smad pathway genes are altered with
inactive TGF-β signal, but the mechanisms remain unclear. RNA-sequencing results showed …
inactive TGF-β signal, but the mechanisms remain unclear. RNA-sequencing results showed …
The role of oxidative stress and cellular senescence in the pathogenesis of metabolic associated fatty liver disease and related hepatocellular carcinoma
Hepatocellular carcinoma (HCC) represents a worryingly increasing cause of malignancy-
related mortality, while Metabolic Associated Fatty Liver Disease (MAFLD) is going to …
related mortality, while Metabolic Associated Fatty Liver Disease (MAFLD) is going to …
MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth
A Kurden-Pekmezci, E Cakiroglu, S Eris, FA Mazi… - Life Sciences, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the
third leading cause of cancer-related deaths worldwide. Despite recent advances in …
third leading cause of cancer-related deaths worldwide. Despite recent advances in …
Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor …
R Arefnezhad, S Ashna… - Cell Biology …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high death
rate in the world. The molecular mechanisms related to the pathogenesis of HCC have not …
rate in the world. The molecular mechanisms related to the pathogenesis of HCC have not …
The paracaspase MALT1 is a downstream target of Smad3 and potentiates the crosstalk between TGF-β and NF-kB signaling pathways in cancer cells
TGF-β signaling mediates its biological effects by engaging canonical Smad proteins and
crosstalking extensively with other signaling networks, including the NF-kB pathway. The …
crosstalking extensively with other signaling networks, including the NF-kB pathway. The …
[HTML][HTML] Oncogenic roles of LINC01234 in various forms of human cancer
M Kong, X Yu, Q Zheng, S Zhang, W Guo - Biomedicine & …, 2022 - Elsevier
Abnormal expression of long non-coding RNAs (lncRNAs) plays an essential role in various
malignant neoplasia. As a newly identified lncRNA, LINC01234 is abnormally expressed in …
malignant neoplasia. As a newly identified lncRNA, LINC01234 is abnormally expressed in …
Key oncogenic signaling pathways affecting tumor-infiltrating lymphocytes infiltration in hepatocellular carcinoma: basic principles and recent advances
X Wang, Z Yuan, Z Li, X He, Y Zhang, X Wang… - Frontiers in …, 2024 - frontiersin.org
The incidence of hepatocellular carcinoma (HCC) ranks first among primary liver cancers,
and its mortality rate exhibits a consistent annual increase. The treatment of HCC has …
and its mortality rate exhibits a consistent annual increase. The treatment of HCC has …
Effect of novel AKT inhibitor Vevorisertib as single agent and in combination with Sorafenib on hepatocellular carcinoma in a cirrhotic rat model
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality
worldwide. The AKT pathway is often activated in HCC cases, and a longer exposure to …
worldwide. The AKT pathway is often activated in HCC cases, and a longer exposure to …