Elevating the levels of calcium ions exacerbate Alzheimer's disease via inducing the production and aggregation of β-amyloid protein and phosphorylated tau

PP Guan, LL Cao, P Wang - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease with a high incidence rate. The
main pathological features of AD are β-amyloid plaques (APs), which are formed by β …

Is vasomotion in cerebral arteries impaired in Alzheimer's disease?

LY Di Marco, E Farkas, C Martin… - Journal of …, 2015 - content.iospress.com
A substantial body of evidence supports the hypothesis of a vascular component in the
pathogenesis of Alzheimer's disease (AD). Cerebral hypoperfusion and blood-brain barrier …

Soluble forms of tau are toxic in Alzheimer's disease

K Kopeikina, B Hyman, T Spires-Jones - Translational neuroscience, 2012 - degruyter.com
Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau,
is a hallmark of Alzheimer's disease. NFT have been considered causative of neuronal …

Intracellular Ca2+ stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer's disease

C Lerdkrai, N Asavapanumas… - Proceedings of the …, 2018 - National Acad Sciences
Neuronal hyperactivity is the emerging functional hallmark of Alzheimer's disease (AD) in
both humans and different mouse models, mediating an impairment of memory and …

The cannabinoids, CBDA and THCA, rescue memory deficits and reduce amyloid-beta and tau pathology in an Alzheimer's disease-like mouse model

J Kim, P Choi, YT Park, T Kim, J Ham… - International journal of …, 2023 - mdpi.com
Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol
(THC); however, up to 120 types of phytocannabinoids are present in hemp. Hemp leaves …

Viral involvement in Alzheimer's disease

A Sait, C Angeli, AJ Doig, PJR Day - ACS chemical neuroscience, 2021 - ACS Publications
Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …

[HTML][HTML] Targeting neural hyperactivity as a treatment to stem progression of late-onset Alzheimer's disease

RP Haberman, A Branch, M Gallagher - Neurotherapeutics, 2017 - Elsevier
Sporadic late-onset Alzheimer's disease (LOAD), the most common form of dementia in the
elderly, causes progressive and severe loss of cognitive abilities. With greater numbers of …

Impairment of in vivo calcium signaling in amyloid plaque-associated microglia

B Brawek, B Schwendele, K Riester, S Kohsaka… - Acta …, 2014 - Springer
Neuroinflammation is a hallmark of Alzheimer's disease (AD) both in man and in multiple
mouse models, and epidemiological studies link the use of anti-inflammatory drugs with a …

Healthy brain aging: Interplay between reactive species, inflammation and energy supply

O Garaschuk, HM Semchyshyn, VI Lushchak - Ageing research reviews, 2018 - Elsevier
Brains' high energy expenditure with preferable utilization of glucose and ketone bodies,
defines the specific features of its energy homeostasis. The extensive oxidative metabolism …

Regulation of intrinsic excitability: Roles for learning and memory, aging and Alzheimer's disease, and genetic diversity

AR Dunn, CC Kaczorowski - Neurobiology of Learning and Memory, 2019 - Elsevier
Plasticity of intrinsic neuronal excitability facilitates learning and memory across multiple
species, with aberrant modulation of this process being linked to the development of …