Elevating the levels of calcium ions exacerbate Alzheimer's disease via inducing the production and aggregation of β-amyloid protein and phosphorylated tau
PP Guan, LL Cao, P Wang - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease with a high incidence rate. The
main pathological features of AD are β-amyloid plaques (APs), which are formed by β …
main pathological features of AD are β-amyloid plaques (APs), which are formed by β …
Is vasomotion in cerebral arteries impaired in Alzheimer's disease?
A substantial body of evidence supports the hypothesis of a vascular component in the
pathogenesis of Alzheimer's disease (AD). Cerebral hypoperfusion and blood-brain barrier …
pathogenesis of Alzheimer's disease (AD). Cerebral hypoperfusion and blood-brain barrier …
Soluble forms of tau are toxic in Alzheimer's disease
K Kopeikina, B Hyman, T Spires-Jones - Translational neuroscience, 2012 - degruyter.com
Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau,
is a hallmark of Alzheimer's disease. NFT have been considered causative of neuronal …
is a hallmark of Alzheimer's disease. NFT have been considered causative of neuronal …
Intracellular Ca2+ stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer's disease
C Lerdkrai, N Asavapanumas… - Proceedings of the …, 2018 - National Acad Sciences
Neuronal hyperactivity is the emerging functional hallmark of Alzheimer's disease (AD) in
both humans and different mouse models, mediating an impairment of memory and …
both humans and different mouse models, mediating an impairment of memory and …
The cannabinoids, CBDA and THCA, rescue memory deficits and reduce amyloid-beta and tau pathology in an Alzheimer's disease-like mouse model
J Kim, P Choi, YT Park, T Kim, J Ham… - International journal of …, 2023 - mdpi.com
Most studies related to hemp are focused on Cannabidiol (CBD) and Tetrahydrocannabinol
(THC); however, up to 120 types of phytocannabinoids are present in hemp. Hemp leaves …
(THC); however, up to 120 types of phytocannabinoids are present in hemp. Hemp leaves …
Viral involvement in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …
[HTML][HTML] Targeting neural hyperactivity as a treatment to stem progression of late-onset Alzheimer's disease
Sporadic late-onset Alzheimer's disease (LOAD), the most common form of dementia in the
elderly, causes progressive and severe loss of cognitive abilities. With greater numbers of …
elderly, causes progressive and severe loss of cognitive abilities. With greater numbers of …
Impairment of in vivo calcium signaling in amyloid plaque-associated microglia
B Brawek, B Schwendele, K Riester, S Kohsaka… - Acta …, 2014 - Springer
Neuroinflammation is a hallmark of Alzheimer's disease (AD) both in man and in multiple
mouse models, and epidemiological studies link the use of anti-inflammatory drugs with a …
mouse models, and epidemiological studies link the use of anti-inflammatory drugs with a …
Healthy brain aging: Interplay between reactive species, inflammation and energy supply
Brains' high energy expenditure with preferable utilization of glucose and ketone bodies,
defines the specific features of its energy homeostasis. The extensive oxidative metabolism …
defines the specific features of its energy homeostasis. The extensive oxidative metabolism …
Regulation of intrinsic excitability: Roles for learning and memory, aging and Alzheimer's disease, and genetic diversity
AR Dunn, CC Kaczorowski - Neurobiology of Learning and Memory, 2019 - Elsevier
Plasticity of intrinsic neuronal excitability facilitates learning and memory across multiple
species, with aberrant modulation of this process being linked to the development of …
species, with aberrant modulation of this process being linked to the development of …