Clinical therapeutics for the regeneration of osteochondral defects (OCD) in the early stages
of osteoarthritis remain an enormous challenge in orthopaedics. For in-depth studies of …

Liver fibrosis is an excessive production, aberrant deposition, and deficit degradation of
extracellular matrix (ECM). Patients with unresolved fibrosis ultimately undergo end-stage …

Platelet recruitment to sites of blood vessel damage is highly dependent upon von
Willebrand factor (VWF). VWF platelet-tethering function is proteolytically regulated by the …

Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the
aggrecan/lectican family. In adults, this proteoglycan serves as a structural macromolecule …

Predicting disease progression remains a particularly challenging endeavor in chronic
degenerative disorders and cancer, thus limiting early detection, risk stratification, and …

Abstract A Disintegrin and Metalloproteinase (ADAM) is a family of proteolytic enzymes that
possess sheddase function and regulate shedding of membrane-bound proteins, growth …

Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly
being associated with regulation of immune cell function. ECM metalloproteinases, including …

Rationale: Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to
proliferative phenotype is a pathological hallmark in various cardiovascular diseases …

Abstract Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular
matrix (ECM), which serve a significant role in the pathological processes of various …

Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized
by the inflammation of the bone leading to degeneration and loss of cartilage function …