Novel analgesics with peripheral targets
CI Ciotu, MJM Fischer - Neurotherapeutics, 2020 - Springer
A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize
these. The review addresses targets acting exclusively or predominantly on sensory …
these. The review addresses targets acting exclusively or predominantly on sensory …
Myocardial fibrosis from the perspective of the extracellular matrix: mechanisms to clinical impact
Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and
constitutes a central pathophysiological process that underlies tissue dysfunction, across …
constitutes a central pathophysiological process that underlies tissue dysfunction, across …
AMD3100 Attenuates Post-Traumatic Osteoarthritis by Maintaining Transforming Growth Factor-β1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3 via …
W Lu, Z He, J Shi, Z Wang, W Wu, J Liu… - Frontiers in …, 2020 - frontiersin.org
AMD3100 is a small-molecule inhibitor of the CXC motif chemokine ligand 12/CXC
chemokine receptor type 4 (CXCL12/CXCR4) axis, while its role in aggrecan metabolism is …
chemokine receptor type 4 (CXCL12/CXCR4) axis, while its role in aggrecan metabolism is …
Low deacetylation degree chitosan oligosaccharide protects against IL-1β induced inflammation and enhances autophagy activity in human chondrocytes
R Cao, H Yu, H Long, H Zhang, C Hao… - Journal of …, 2022 - Taylor & Francis
Osteoarthritis (OA) is a degenerative joint disease, which can lead to joint pain, stiffness,
deformity and dysfunction, that seriously affects the quality of life in patients. At present, the …
deformity and dysfunction, that seriously affects the quality of life in patients. At present, the …
Transcriptomic profiling of mare endometrium at different stages of endometrosis
A Szóstek-Mioduchowska, A Wójtowicz, A Sadowska… - Scientific Reports, 2023 - nature.com
In the current study, transcriptome profiles of mare endometrium, classified into categories I,
IIA, and IIB according to Kenney and Doig, were compared using RNA sequencing …
IIA, and IIB according to Kenney and Doig, were compared using RNA sequencing …
ADAM and ADAMTS disintegrin and metalloproteinases as major factors and molecular targets in vascular malfunction and disease
HF Yang, RA Khalil - Advances in Pharmacology, 2022 - Elsevier
Abstract A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and
Metalloproteinase with Thrombospondin Motifs (ADAMTS) are two closely related families of …
Metalloproteinase with Thrombospondin Motifs (ADAMTS) are two closely related families of …
[PDF][PDF] RETRACTED ARTICLE: 1, 25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages
A Duan, Z Ma, W Liu, K Shen, H Zhou… - Journal of …, 2021 - Taylor & Francis
Duan A, Ma Z, Liu W, et al. J Inflamm Res. 2021; 14: 6523–6542. The Editor and Publisher of
Journal of Inflammation Research wish to retract the published article. Concerns were raised …
Journal of Inflammation Research wish to retract the published article. Concerns were raised …
Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity
M de Assis Lima, SV da Silva, O Serrano-Garrido… - Cellular signalling, 2021 - Elsevier
Abstract ADAMTSs (AD isintegrin And Metalloproteinase with ThromboSpondin motifs) are
secreted proteases dependent on Zn 2+/Ca 2+, involved in physiological and pathological …
secreted proteases dependent on Zn 2+/Ca 2+, involved in physiological and pathological …
Schistocyte detection in artificial intelligence age
Z Zhang, S Yang, X Wang - International Journal of Laboratory …, 2024 - Wiley Online Library
Schistocytes are fragmented red blood cells produced as a result of mechanical damage to
erythrocytes, usually due to microangiopathic thrombotic diseases or mechanical factors …
erythrocytes, usually due to microangiopathic thrombotic diseases or mechanical factors …
Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ
Peters plus syndrome, characterized by defects in eye and skeletal development with
isolated cases of ventriculomegaly/hydrocephalus, is caused by mutations in the β3 …
isolated cases of ventriculomegaly/hydrocephalus, is caused by mutations in the β3 …