Exposure of human lung cells to polystyrene microplastics significantly retards cell proliferation and triggers morphological changes

KE Goodman, JT Hare, ZI Khamis, T Hua… - Chemical research in …, 2021 - ACS Publications
Microplastics in the environment produced by decomposition of globally increasing waste
plastics have become a dominant component of both water and air pollution. To examine the …

Molecular mechanisms underlying mitochondrial damage, endoplasmic reticulum stress, and oxidative stress induced by environmental pollutants

K Li, Y Geng, B Lin, Z Xi - Toxicology Research, 2023 - academic.oup.com
Mitochondria and endoplasmic reticulum (ER) are essential organelles playing pivotal roles
in the regulation of cellular metabolism, energy production, and protein synthesis. In …

Connecting the oxidative potential of secondary organic aerosols with reactive oxygen species in exposed lung cells

PH Chowdhury, Q He, R Carmieli, C Li… - Environmental …, 2019 - ACS Publications
It has been hypothesized that the cytotoxicity of secondary organic aerosols (SOA) is
mediated through the formation of reactive oxygen species (ROS) in the exposed cells …

[HTML][HTML] Genomic approach to the assessment of adverse effects of particulate matters on skin cancer and other disorders and underlying molecular mechanisms

NG Kee, HS Kim, H Choi, HJ Kim… - Journal of Cancer …, 2021 - ncbi.nlm.nih.gov
Air pollutants are in the spotlight because the human body can easily be exposed to them.
Among air pollutants, the particulate matter (PM) represents one of the most serious …

Inhibition of RAGE attenuates cigarette smoke-induced lung epithelial cell damage via RAGE-mediated Nrf2/DAMP signaling

H Lee, J Lee, SH Hong, I Rahman… - Frontiers in …, 2018 - frontiersin.org
The oxidative stress and cellular apoptosis by environmental factor including cigarette
smoke induces alveolar airway remodeling leading to chronic obstructive pulmonary …

Seasonally varied cytotoxicity of organic components in PM2. 5 from urban and industrial areas of a Chinese megacity

Q Chen, XS Luo, Y Chen, Z Zhao, Y Hong, Y Pang… - Chemosphere, 2019 - Elsevier
The atmospheric fine particulate matters (PM 2.5) induce significant negative effects on
human health, such as in the form of oxidative stress and pro-inflammatory response …

Uptake and toxicity of respirable carbon-rich uranium-bearing particles: insights into the role of particulates in uranium toxicity

E El Hayek, S Medina, J Guo… - … science & technology, 2021 - ACS Publications
Particulate matter (PM) presents an environmental health risk for communities residing close
to uranium (U) mine sites. However, the role of the particulate form of U on its cellular toxicity …

Polystyrene nanoplastics mediate oxidative stress, senescence, and apoptosis in a human alveolar epithelial cell line

C Milillo, E Aruffo, P Di Carlo, A Patruno… - Frontiers in Public …, 2024 - frontiersin.org
Background Nanoplastics, an emerging form of pollution, are easily consumed by organisms
and pose a significant threat to biological functions due to their size, expansive surface area …

Epidermal growth factor receptor (EGFR)—MAPK—nuclear factor (NF)‐κB—IL8: A possible mechanism of particulate matter (PM) 2.5‐induced lung toxicity

SC Jeong, Y Cho, MK Song, E Lee… - Environmental …, 2017 - Wiley Online Library
Airway inflammation plays a central role in the pathophysiology of diverse pulmonary
diseases. In this study, we investigated whether exposure to particulate matter (PM) 2.5, a …

Potential cytotoxicity of PM2. 5–bound PAHs and toxic metals collected from areas with different traffic densities on human lung epithelial cells (A549)

T Rahmatinia, M Kermani, M Farzadkia… - … of Environmental Health …, 2021 - Springer
Laboratory and epidemiological researches have indicated that ambient air particulate
matter have a plays critical role in causing diseases. The current research evaluated the …