Antagonistic antibodies targeting the inhibitory immune-checkpoint receptor PD-1 or its
ligand PD-L1 are used to treat a wide range of cancer types and can substantially improve …

Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor
emerging as an important clinical target in inflammatory diseases. However, little is known …

Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains
unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in …

Targeting TEAD autopalmitoylation has been proposed as a therapeutic approach for YAP-
dependent cancers. Here we show that TEAD palmitoylation inhibitor MGH-CP1 and …

Glucose transporter GLUT1 is a transmembrane protein responsible for the uptake of
glucose into the cells of many tissues through facilitative diffusion. Plasma membrane (PM) …

Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …

Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Checkpoint blockade therapy targeting the programmed-death ligand 1 (PD-L1) and its
receptor programmed cell death 1 promotes T-cell-mediated immunosurveillance against …

Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …