Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

Objectives To identify genes that may play a role in urethral stricture and summarize the
results of studies that have documented variations in gene expression among individuals …

Simple Summary Thermal ablation has been confirmed to increase the percentage of
functional CD8+ T cells in the tumor microenvironment (TME) and activate tumor-specific T …

Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease with complex
genetic basis and still no clear etiology. Multiple intertwined layers of immune system …

SARS-CoV-2 infection is characterized by several clinical manifestations, ranging from the
absence of symptoms to severe forms that necessitate intensive care treatment. It is known …

Background Breast cancers exhibit considerable heterogeneity in their biology, immunology,
and prognosis. Currently, no validated, serum protein-based tools are available to evaluate …

Purpose Clinical application of immunotherapy represented by Programmed Death-1 (PD-1)
monoclonal antibody has changed the treatment paradigm for colorectal cancer (CRC), and …

Immune cell migration is required for the development of an effective and robust immune
response. This elegant process is regulated by both cellular and environmental factors, with …

Homeostasis of the host immune system is regulated by white blood cells with a variety of
cell surface receptors for cytokines. Chemotactic cytokines (chemokines) activate their …

The prediction of colorectal cancer (CRC) response to palliative chemotherapy (CTH) is still
difficult. Patients at a higher risk of progression may benefit from more aggressive treatment …