Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …

Fluorescent compounds have become indispensable tools for imaging molecular activities
in the living cell. 4, 4-Difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) is currently one of …

The last decade has witnessed significant advance in the imaging of living systems using
fluorescent markers. This progress has been primarily associated with the discovery of …

The explosive growth of single-molecule techniques is transforming our understanding of
biology, helping to develop new physics inspired by emergent biological processes, and …

The WD40 repeat protein 5 (WDR5) is a nuclear hub that critically influences gene
expression by interacting with transcriptional regulators. Utilizing the WDR5 binding motif …

Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically
notable viruses such as the 4 dengue virus serotypes (DENV-1–4). Distinguishing DENVs …

With a spatial resolution breaking the diffraction limit of light, superresolution imaging allows
the visualization of detailed structures of organelles such as mitochondria, cytoskeleton …

Phage display is the most widely used method for selecting binding molecules from
recombinant antibody libraries. However, validation of the phage antibodies often requires …

Many dynamic interactions within the cell microenvironment modulate cell behavior and cell
fate. However, the pathways and mechanisms behind cell–cell or cell–extracellular matrix …

细胞是生物体的基本结构和功能单位, 其内部复杂的组织结构, 相互作用及动力学过程等决定着
整个生物体的生命形态和生命过程. 开展活体状态下细胞结构和功能研究 …