Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Antibacterial agents target the products of essential genes but rarely achieve complete
target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic …

Latent tuberculosis infection (LTBI) is a subclinical mycobacterial infection defined on the
basis of cellular immune response to mycobacterial antigens. The tuberculin skin test (TST) …

While it is known that a substantial proportion of individuals with tuberculosis disease (TB)
present subclinically, usually defined as bacteriologically-confirmed but negative on …

A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …

Background Identification of blood biomarkers that prospectively predict progression of
Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

While a third of the world carries the burden of tuberculosis, disease control has been
hindered by a lack of tools, including a rapid, point-of-care diagnostic and a protective …