Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Tissue fibrosis and extracellular matrix (ECM) stiffening promote tumour progression. The
mechanisms by which ECM regulates its contacting cells have been extensively studied …

Background Resistance to ferroptosis, a regulated cell death caused by iron‐dependent
excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma …

The tumor microbiome is increasingly implicated in cancer progression and resistance to
chemotherapy. In pancreatic ductal adenocarcinoma (PDAC), high intratumoral loads of …

Objective Pancreatic ductal adenocarcinoma (PDAC) shows a remarkable predilection for
liver metastasis. Pro-oncogenic secretome delivery and trafficking via exosomes are crucial …

A hallmark of pancreatic tumors is their highly desmoplastic stroma composed of fibroblasts,
immune cells, and a dense network of collagen fibers. Tumor-associated macrophages are …

Objective Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and
lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined …

The patient population suffering from pancreatic ductal adenocarcinoma (PDAC) presents,
as a whole, with a high degree of molecular tumor heterogeneity. The heterogeneity of …

Transforming growth factor-β (TGF-β) signaling is essential in embryo development and
maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on …