Proteomics and phosphoproteomics of failing human left ventricle identifies dilated cardiomyopathy-associated phosphorylation of CTNNA3

CJ Reitz, M Tavassoli, DH Kim… - Proceedings of the …, 2023 - National Acad Sciences
The prognosis and treatment outcomes of heart failure (HF) patients rely heavily on disease
etiology, yet the majority of underlying signaling mechanisms are complex and not fully …

Proteomics of the Heart

OA Karpov, A Stotland, K Raedschelders… - Physiological …, 2024 - journals.physiology.org
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

[HTML][HTML] Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)

M Valero-Muñoz, EL Saw, RM Hekman… - Frontiers in …, 2022 - frontiersin.org
Although the prevalence of heart failure with preserved ejection fraction (HFpEF) is
increasing, evidence-based therapies for HFpEF remain limited, likely due to an incomplete …

[HTML][HTML] A novel ferroptosis related gene signature is associated with prognosis in patients with ovarian serous cystadenocarcinoma

Z Yu, H He, Y Chen, Q Ji, M Sun - Scientific Reports, 2021 - nature.com
Ovarian cancer (OV) is a common type of carcinoma in females. Many studies have reported
that ferroptosis is associated with the prognosis of OV patients. However, the mechanism by …

Integrative proteomics-metabolomics strategy reveals the mechanism of hepatotoxicity induced by Fructus Psoraleae

J Duan, W Dong, L Xie, S Fan, Y Xu, Y Li - Journal of proteomics, 2020 - Elsevier
Fructus Psoraleae (FP), one of the significant traditional Chinese medicines, has been
reported to cause hepatotoxicity. However, the mechanism remains undetermined and the …

[HTML][HTML] Bottom-up proteomic analysis of human adult cardiac tissue and isolated cardiomyocytes

M Wojtkiewicz, LB Luecke, C Castro… - Journal of molecular and …, 2022 - Elsevier
The heart is composed of multiple cell types, each with a specific function. Cell-type-specific
approaches are necessary for defining the intricate molecular mechanisms underlying …

[HTML][HTML] Serum proteomic changes in dogs with different stages of chronic heart failure

A Saril, M Kocaturk, K Shimada, A Uemura, E Akgün… - Animals, 2022 - mdpi.com
Simple Summary Canine MMVD is a progressive chronic disease with variable clinical
signs, with some patients remaining completely asymptomatic while others develop CHF …

[HTML][HTML] The small GTPases Rab27b regulates mitochondrial fatty acid oxidative metabolism of cardiac mesenchymal stem cells

Y Jin, Y Shen, X Su, J Cai, Y Liu… - Frontiers in Cell and …, 2020 - frontiersin.org
Cardiac mesenchymal stem cells (C-MSCs) are endogenous cardiac stromal cells that play
a crucial role in maintaining normal cardiac function. Rab27b is a member of the small …

[HTML][HTML] Cardiac resynchronization therapy in heart failure patients by using left bundle branch pacing

Y Gu, Y Li, Y Zhu, X Lin, T Tian, Q Zhang… - Frontiers in …, 2022 - frontiersin.org
Background Left bundle branch pacing (LBBP) is emerging as an effective alternative to
achieve cardiac resynchronization therapy (CRT) and improve heart function. The purpose …

[HTML][HTML] Insight into the underlying molecular mechanism of dilated cardiomyopathy through integrative analysis of data mining, iTRAQ-PRM proteomics and …

H Xiong, Z Zheng, C Zhao, M Zhao, Q Wang, P Zhang… - Proteome Science, 2023 - Springer
Background DCM is a common cardiomyopathy worldwide, which is characterized by
ventricular dilatation and systolic dysfunction. DCM is one of the most widespread diseases …