Polarized T helper cell (Th cell) responses are important determinants of host protection. Th
cell subsets tailor their functional repertoire of cytokines to their cognate antigens to …

Regulatory T cells (Tregs) are essential to control immune system responses to innocuous
self-specificities, intestinal and environmental antigens. However, they may also interfere …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

Malaria is a devastating infectious disease and significant global health burden caused by
the bite of a Plasmodium-infected female Anopheles mosquito. Gut microbiota was recently …

Background Malaria in pregnancy (MIP) causes higher morbidity in primigravid compared to
multigravid women; however, the correlates and mechanisms underlying this gravidity …

Background CD4+ Th1 cells producing IFN-γ are required to eradicate intracellular
pathogens, however if uncontrolled these cells can cause immunopathology. The cytokine IL …

Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory
responses across the immune landscape. These regulatory responses help to protect …

Progress in the discovery of potent antibodies for therapeutic and research purposes has
been accelerated by mining the antibody repertoire of plasma cells and plasmablasts …

The development of highly effective malaria vaccines and improvement of drug-treatment
protocols to boost antiparasitic immunity are critical for malaria elimination. However, the …

Maintenance of CD4 T cells during chronic infections is vital for limiting pathogen burden
and disease recrudescence. Although inhibitory receptor expression by CD4 T cells is …