Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide, particularly
in China. Despite the development of HCC treatment strategies, the survival rate remains …

Hepatocellular carcinoma (HCC) carries a dismal prognosis, with advanced disease being
resistant to both radiotherapy and conventional cytotoxic drugs, whilst anti-angiogenic drugs …

Background Hepatocellular carcinoma (HCC) is a highly refractory cancer associated with
increasing mortality, which currently lacks effective treatment options. Interleukin-24 (IL-24) …

Interleukin 24 (mda-7/IL-24) has been classified as an anti-cancer gene for its ability to
selectively induce cell death in cancer cells while having little to no effect on normal cells …

MDA7/IL24 is a member of the IL‑10 gene family that functions as a cytokine. Notably, supra‑
physiological endogenous MDA7 levels have been indicated to suppress tumor growth and …

Background Hepatocellular carcinoma (HCC) has a dismal 5-year-survival rate of 10%, so
novel strategies are warranted. IL-24 mediates anti-tumor activity reducing STAT3 …

Approximately 25% of osteosarcoma patients present with clinically detectable metastatic
disease at the time of initial diagnosis. High‑dose chemotherapy and/or surgery for the …

Activation of hepatic stellate cells (HSCs) is the pivotal event during liver fibrosis. Interleukin
(IL)‑24/melanoma differentiation‑associated gene‑7 (mda‑7) has attracted attention in the …

Multidrug resistance is the main cause for failure of chemotherapy. Melanoma differentiation
associated gene‐7/interleukin‐24 (mda‐7/IL‐24) has been implicated in the inhibition of …

摘要目的: 探讨携带人mda-7/IL-24 基因的溶瘤腺病毒SG600-IL24 对肝癌细胞选择性杀伤效应
的机制. 方法: 构建携带人mda-7/IL-24 基因的溶瘤腺病毒SG600-IL24 后 …