In the early 2000s, Tawfik presented his 'New View'on enzyme evolution, highlighting the
role of conformational plasticity in expanding the functional diversity of limited repertoires of …

The escalating global demand for rare earth elements (REEs) and the overabundance of
REE-containing waste require innovative technologies for REE recovery from waste to …

How do proteins evolve? How do changes in sequence mediate changes in protein
structure, and in turn in function? This question has multiple angles, ranging from …

With the growing acceptance of the contribution of protein conformational ensembles to
enzyme catalysis and regulation, research in the field of protein dynamics has shifted toward …

Abstract Enzymes offering chemo-, regio-, and stereoselectivity enable the asymmetric
synthesis of high-value chiral molecules. Unfortunately, the drawback that naturally …

Recent years have seen an explosion of interest in understanding the physicochemical
parameters that shape enzyme evolution, as well as substantial advances in computational …

De novo design of complex protein folds using solely computational means remains a
significant challenge. Here, we use a robust deep learning pipeline to design complex folds …

Enzymes have been shaped by evolution over billions of years to catalyse the chemical
reactions that support life on earth. Dispersed in the literature, or organised in online …

The ability to design stable proteins with custom-made functions is a major goal in
biochemistry with practical relevance for our environment and society. Understanding and …

Recent advancements in specialized large-scale architectures for training images and
language have profoundly impacted the field of computer vision and natural language …