B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …

The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain
containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced
numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins …

Targeted therapies that suppress B cell receptor (BCR) signaling have emerged as
promising agents in autoimmune disease and B cell malignancies. Bruton's tyrosine kinase …

Depletion of intracellular calcium (Ca2+) stores induces store-operated Ca2+ (SOC) entry
across the plasma membrane (PM). STIM1, a putative Ca2+ sensor in the endoplasmic …

Simple Summary Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes, myeloid cells
and platelets. Since the launch of the first in class Btk-inhibitor (BTKi) ibrutinib in 2013, the …

Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and
oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form …

Alterations in the cytosolic concentration of calcium ions (Ca2+) transmit information that is
crucial for the development and function of B cells. Cytosolic Ca2+ concentration is …

Bruton's tyrosine kinase (BTK) mediates B cell signaling and is also present in innate
immune cells but not T cells. BTK propagates B cell receptor (BCR) responses to antigen …