The B cell antigen receptor (BCR) is coupled to the mobilization of Ca 2+ by the protein-
tyrosine kinase, Syk. Syk, recruited to the clustered BCR, becomes phosphorylated on three …

The Tec family of protein tyrosine kinases play an important role in signaling through antigen-
receptors such as the TCR, BCR and Fcε receptor. Recent studies have generated new …

Malignant B cells accumulate in the peripheral blood, bone marrow, and lymphoid organs of
patients with chronic lymphocytic leukemia (CLL). In the tissue compartments, CLL shape a …

Introduction B-cell activation triggers the release of endoplasmic reticulum calcium stores
through the store-operated calcium entry (SOCE) pathway resulting in calcium influx by …

Mast cells play a central role in type I hypersensitivity reactions and allergic disorders such
as anaphylaxis and asthma. Activation of mast cells, through a cascade of phosphorylation …

The B-cell receptor (BCR) complex and its associated protein tyrosine kinases play a critical
role in the development, proliferation, and survival of normal or malignant B cells. Regulated …

Approximately 20% of patients with acute myeloid leukaemia (AML) have a mutation in FMS-
like-tyrosine-kinase-3 (FLT3). FLT3 is a trans-membrane receptor with a tyrosine kinase …

The preliminary evidence for the involvement of complement in promoting primary humoral
responses dates back over a quarter of a century. However, it is only in the course of the …

Protein kinases are implicated in multiple diseases such as cancer, diabetes, cardiovascular
diseases, and central nervous system disorders. Identification of kinase substrates is critical …

Background: B lymphocytes (B cells) are essential in humoral response, and their activation
is an important first step for the production of antibodies. However, aberrant B-cell activation …