BCR targets cyclin D2 via Btk and the p85α subunit of PI3-K to induce cell cycle progression in primary mouse B cells
J Glassford, I Soeiro, SM Skarell, L Banerji, M Holman… - Oncogene, 2003 - nature.com
The p85α subunit of PI3-K and Btk are two crucial components of the B-cell receptor (BCR)
signalling pathway. In the present study, we showed that primary splenic B cells from p85α …
signalling pathway. In the present study, we showed that primary splenic B cells from p85α …
ABBV-105, a selective and irreversible inhibitor of Bruton's tyrosine kinase, is efficacious in multiple preclinical models of inflammation
C Goess, CM Harris, S Murdock… - Modern …, 2019 - academic.oup.com
Objectives: Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase required for
intracellular signaling downstream of multiple immunoreceptors. We evaluated ABBV-105, a …
intracellular signaling downstream of multiple immunoreceptors. We evaluated ABBV-105, a …
[PDF][PDF] Genetic defects in B-cell development and their clinical consequences
Expression of selected genes in hematopoietic stem cells has been identified as a regulator
of differentiation of B cells in the liver and bone marrow. Moreover, naïve B cells expressing …
of differentiation of B cells in the liver and bone marrow. Moreover, naïve B cells expressing …
Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity
S Middendorp, AJE Zijlstra, R Kersseboom… - Blood, 2005 - ashpublications.org
During B-cell development in the mouse, Bruton tyrosine kinase (Btk) and the adaptor
protein SLP-65 (Src homology 2 [SH2] domain-containing leukocyte protein of 65 kDa) limit …
protein SLP-65 (Src homology 2 [SH2] domain-containing leukocyte protein of 65 kDa) limit …
The autoinhibitory C-terminal SH2 domain of phospholipase C–γ2 stabilizes B cell receptor signalosome assembly
J Wang, H Sohn, G Sun, JD Milner, SK Pierce - Science signaling, 2014 - science.org
The binding of antigen to the B cell receptor (BCR) stimulates the assembly of a signaling
complex (signalosome) composed initially of the kinases Lyn, spleen tyrosine kinase (Syk) …
complex (signalosome) composed initially of the kinases Lyn, spleen tyrosine kinase (Syk) …
Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition
Dysregulation of the oncogenic transcription factor MYC induces B-cell transformation and is
a driver for B-cell non-Hodgkin lymphoma (B-NHL). MYC overexpression in B-NHL is …
a driver for B-cell non-Hodgkin lymphoma (B-NHL). MYC overexpression in B-NHL is …
Clonal B cells in Waldenström's macroglobulinemia exhibit functional features of chronic active B-cell receptor signaling
Waldenström's macroglobulinemia (WM) is a B-cell non-Hodgkin's lymphoma (B-NHL)
characterized by immunoglobulin M (IgM) monoclonal gammopathy and the medullary …
characterized by immunoglobulin M (IgM) monoclonal gammopathy and the medullary …
Diverse phosphorylation patterns of B cell receptor-associated signaling in naive and memory human B cells revealed by phosphoflow, a powerful technique to study …
FR Toapanta, PJ Bernal, MB Sztein - Frontiers in cellular and infection …, 2012 - frontiersin.org
Following interaction with cognate antigens, B cells undergo cell activation, proliferation,
and differentiation. Ligation of the B cell receptor (BCR) leads to the phosphorylation of BCR …
and differentiation. Ligation of the B cell receptor (BCR) leads to the phosphorylation of BCR …
SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins
T Oellerich, M Grønborg, K Neumann, HH Hsiao… - Molecular & Cellular …, 2009 - ASBMB
Understanding intracellular signal transduction by cell surface receptors requires
information about the precise order of relevant modifications on the early transducer …
information about the precise order of relevant modifications on the early transducer …
Synergistic targeting of the regulatory and catalytic subunits of PI3Kδ in mature B-cell malignancies
JD Cooney, AP Lin, D Jiang, L Wang, AN Suhasini… - Clinical Cancer …, 2018 - AACR
Purpose: Aberrant activation of the B-cell receptor (BCR) is implicated in the pathogenesis of
mature B-cell tumors, a concept validated in part by the clinical success of inhibitors of the …
mature B-cell tumors, a concept validated in part by the clinical success of inhibitors of the …