Recruitment of leukocytes into inflamed tissue is a key component of the immune system.
The activation of integrins on leukocytes is required for their recruitment into the inflamed …

The inhibitor of Bruton tyrosine kinase γ (IBtkγ) is a negative regulator of the Bruton tyrosine
kinase (Btk), which plays a major role in B-cell differentiation; however, the mechanisms of …

The complexity of cancer signaling networks limits the efficacy of most single-agent
treatments and brings about challenges in identifying effective combinatorial therapies. In …

While it is currently estimated that 40-50% of eukaryotic proteins are phosphorylated, little is
known about the frequency and local effects of phosphorylation near pharmaceutical …

ITK-SYK, a novel fusion tyrosine kinase (FTK) resulting from a recurrent t (5; 9)(q33; q22),
was recently identified in a poorly understood subset of peripheral T-cell lymphomas …

Bruton's tyrosine kinase (Btk) propagates B cell signaling, and BTK inhibitors are in clinical
trials for autoimmune disease. Although autoreactive B cells fail to develop in the absence of …

The B cell antigen receptor (BCR) is the sensor on the B cell surface that surveys foreign
molecules (antigen) in our bodies and activates B cells to generate antibody responses …

Introduction: Btk is a tyrosine kinase dysregulated in several B-cell malignancies and
autoimmune diseases, and this has given rise to a search for Btk inhibitors. Nevertheless …

Since their discovery as signaling subunits of the B cell antigen receptor (BCR), Ig-α and Ig-
β are discussed to serve either a redundant or distinct function for B cell development …

Abstract The Protein kinase B (AKT) regulates a plethora of intracellular signaling proteins to
fine-tune signaling of multiple pathways. Here, we found that following B-cell receptor (BCR) …