Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance

D Wu, ED Lewis, M Pae, SN Meydani - Frontiers in immunology, 2019 - frontiersin.org
It is well-established that the nutritional deficiency or inadequacy can impair immune
functions. Growing evidence suggests that for certain nutrients increased intake above …

n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions

PC Calder - Proceedings of the Nutrition Society, 2013 - cambridge.org
Numerous effects of n-3 fatty acids EPA and DHA on functional responses of cells involved
in inflammation and immunity have been described. Fatty acid-induced modifications in …

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

N Patsoukis, K Bardhan, P Chatterjee, D Sari… - Nature …, 2015 - nature.com
During activation, T cells undergo metabolic reprogramming, which imprints distinct
functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage …

Inflammation and the two-hit hypothesis of schizophrenia

KA Feigenson, AW Kusnecov, SM Silverstein - … & Biobehavioral Reviews, 2014 - Elsevier
The high societal and individual cost of schizophrenia necessitates finding better, more
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …

The impact of weaning stress on gut health and the mechanistic aspects of several feed additives contributing to improved gut health function in weanling piglets—A …

SD Upadhaya, IH Kim - Animals, 2021 - mdpi.com
Simple Summary The current review aimed to provide an overview on the problems
associated with weaning with a special focus on gut health, and also highlighted the …

An emerging player in knee osteoarthritis: the infrapatellar fat pad

A Ioan-Facsinay, M Kloppenburg - Arthritis research & therapy, 2013 - Springer
The role of inflammation in the development, progression, and clinical features of
osteoarthritis has become an area of intense research in recent years. This led to the …

COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance

R Poorani, AN Bhatt, BS Dwarakanath… - European journal of …, 2016 - Elsevier
Polyunsaturated fatty acids (PUFAs) are vital for normal growth and development and
physiological function of various tissues in humans. PUFAs have immunomodulatory actions …

Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β

DA Nicholas, K Zhang, C Hung, S Glasgow, AW Aruni… - PloS one, 2017 - journals.plos.org
Palmitic acid (PA) and other saturated fatty acids are known to stimulate pro-inflammatory
responses in human immune cells via Toll-like receptor 4 (TLR4). However, the molecular …

Natural compounds of marine origin as inducers of immunogenic cell death (ICD): potential role for cancer interception and therapy

C Sansone, A Bruno, C Piscitelli, D Baci, A Fontana… - Cells, 2021 - mdpi.com
Regulated cell death (RCD) has always been considered a tolerogenic event. Immunogenic
cell death (ICD) occurs as a consequence of tumour cell death accompanied by the release …

Omega-3 polyunsaturated fatty acids impinge on CD4+ T cell motility and adipose tissue distribution via direct and lipid mediator-dependent effects

D Cucchi, D Camacho-Munoz, M Certo… - Cardiovascular …, 2020 - academic.oup.com
Aims Adaptive immunity contributes to the pathogenesis of cardiovascular metabolic
disorders (CVMD). The omega-3 polyunsaturated fatty acids (n-3PUFA) are beneficial for …