Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

AL Durham, MY Speer, M Scatena… - Cardiovascular …, 2018 - academic.oup.com
Vascular calcification is associated with a significant increase in all-cause mortality and
atherosclerotic plaque rupture. Calcification has been determined to be an active process …

Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus

K Yahagi, FD Kolodgie, C Lutter, H Mori… - … , and vascular biology, 2017 - Am Heart Assoc
The continuing increase in the prevalence of diabetes mellitus in the general population is
predicted to result in a higher incidence of cardiovascular disease. Although the …

Klotho deficiency causes heart aging via impairing the Nrf2-GR pathway

K Chen, S Wang, QW Sun, B Zhang, M Ullah… - Circulation …, 2021 - Am Heart Assoc
Rationale: Cardiac aging is an important contributing factor for heart failure, which affects a
large population but remains poorly understood. Objective: The purpose of this study is to …

Targeting vascular calcification in chronic kidney disease

AJ Nelson, P Raggi, M Wolf, AM Gold… - Basic to Translational …, 2020 - jacc.org
Cardiovascular (CV) disease remains an important cause of morbidity and mortality for
patients with chronic kidney disease (CKD). Although clustering of traditional risk factors with …

Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho

S Yamada, CM Giachelli - Bone, 2017 - Elsevier
Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney
disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD …

Arterial calcification in chronic kidney disease: key roles for calcium and phosphate

CM Shanahan, MH Crouthamel, A Kapustin… - Circulation …, 2011 - Am Heart Assoc
Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney
disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is …

[HTML][HTML] Vascular calcification in chronic kidney disease: different bricks in the wall?

M Vervloet, M Cozzolino - Kidney international, 2017 - Elsevier
A high prevalence of vascular calcification (VC) and a high incidence of cardiovascular
events are two key complications of chronic kidney disease. Since most observational …

[PDF][PDF] Clinical practice guideline for the management of chronic kidney disease‐mineral and bone disorder

M Fukagawa, K Yokoyama, F Koiwa… - … Apheresis and Dialysis, 2013 - jsdt.or.jp
Masafumi Fukagawa, 1 Keitaro Yokoyama, 1 Fumihiko Koiwa, 1 Masatomo Taniguchi, 1
Tetsuo Shoji, 1 Junichiro James Kazama, 1 Hirotaka Komaba, 1 Ryoichi Ando, 1 Takatoshi …

Understanding sources of dietary phosphorus in the treatment of patients with chronic kidney disease

K Kalantar-Zadeh, L Gutekunst… - Clinical Journal of the …, 2010 - journals.lww.com
In individuals with chronic kidney disease, high dietary phosphorus (P) burden may worsen
hyperparathyroidism and renal osteodystrophy, promote vascular calcification and …

[HTML][HTML] Fibroblast growth factor 23 is not associated with and does not induce arterial calcification

JJ Scialla, WL Lau, MP Reilly, T Isakova, HY Yang… - Kidney international, 2013 - Elsevier
Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease in
patients with chronic kidney disease. As a potential mediating mechanism, FGF23 induces …