Autoimmune connective tissue diseases are clinically variable, making biomarkers desirable
for assessing future disease risk, supporting early and accurate diagnosis, monitoring …

Abstract Systemic Lupus Erythematosus is a systemic autoimmune disease characterized by
a great heterogenicity in course and clinical manifestations. Although prognosis improved in …

Self-reactive B cells generated through V (D) J recombination in the bone marrow or through
accrual of random mutations in secondary lymphoid tissues are mostly purged or edited to …

Background: Total glucosides of paeony (TGP), extracted from the dried roots of Paeonia
lactiflora Pall., are proven to regulate immune function in various rheumatic diseases. We …

Objectives Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized
by disease flares which can require hospitalization. Our objective was to apply machine …

Aim The Lupus Low Disease Activity State (LLDAS) is a potential treat to target goal in
systemic lupus erythematosus (SLE). SLE patients in LLDAS for more than half of the …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease associated with
hormonal, environmental, and genetic factors and linked to the tolerance breakdown of B …

Introduction The FDA approved the anti-BAFF monoclonal antibody, belimumab, in 2011 for
adult systemic lupus erythematosus (SLE), in 2019 for pediatric SLE, in 2020 for adult lupus …

Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory
disease with extensive clinical variability. In 2011, the anti-BAFF monoclonal antibody …

Objective The aim of this study was to assess whether circulating histone‐specific T cells
represent tools for precision medicine in systemic lupus erythematosus (SLE). Methods …