Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Food is consumed in order to maintain energy balance at homeostatic levels. In addition,
palatable food is also consumed for its hedonic properties independent of energy status …

Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …

Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

Despite the generally held view that alcohol is an unspecific pharmacological agent, recent
molecular pharmacology studies demonstrated that alcohol has only a few known primary …

The popular media and personal anecdotes are rich with examples of stress-induced eating
of calorically dense “comfort foods.” Such behavioral reactions likely contribute to the …

Ghrelin, a circulating orexigenic stomach-derived hormone, has recently been implicated in
extra-homeostatic feeding, increasing food reward and food-motivated behavior. The …

BACKGROUND: Ghrelin is a potent orexigenic hormone that likely impacts eating via
several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic …

We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key
node in the mesolimbic reward system, is important for the rewarding and motivational …

The stomach-derived hormone ghrelin interacts with key CNS circuits regulating energy
balance and body weight. Here we provide evidence that the central ghrelin signaling …