Transcription factors are regulatory proteins that either activate or repress the transcription of
genes via binding to DNA regulatory sequences and regulating recruitment of transcriptional …

The hypoxia-inducible factor (HIF-1), in addition to genetic and epigenetic changes, is
largely responsible for alterations in cell metabolism in hypoxic tumour cells. This …

Loss of articular cartilage through injury or disease presents major clinical challenges also
because cartilage has very poor regenerative capacity, giving rise to the development of …

Purpose: To determine the incidence of Xp11 translocation renal cell carcinoma (RCC) in
adult patients using cytogenetics and immunohistochemstry. Experimental Design …

Cells anchor to substrates by binding to extracellular matrix (ECM). In addition to this
anchoring function however, cell–ECM binding is a mechanism for cells to sense their …

Invasion and metastasis are the major features of malignant tumors that are responsible for
90% of cancer-related deaths. Recently, microRNAs have been discovered to have a role in …

Background Alveolar soft part sarcoma (ASPS) is an orphan malignancy associated with a
rearrangement of transcription factor E3 (TFE3), leading to abnormal MET gene expression …

Background Head and neck squamous cell carcinoma (HNSCC) has had little improvement
in mortality rates in decades. A clearer understanding of the HNSCC tumor …

The receptor tyrosine kinase, c-MET and its ligand hepatocyte growth factor/scatter factor
(HGF/SF) have become leading candidates for targeted cancer therapies. Inappropriate c …

Altered regulation of tyrosine kinase receptors (RTKs) is frequent in solid tumours and it is
often associated with the acquisition of an aggressive phenotype. Thus, therapies targeting …