[HTML][HTML] Single-cell characterization of self-renewing primary trophoblast organoids as modeling of EVT differentiation and interactions with decidual natural killer cells

BM Zhuang, DD Cao, TX Li, XF Liu, MM Lyu, SD Wang… - BMC genomics, 2023 - Springer
Background Extravillous trophoblast cell (EVT) differentiation and its communication with
maternal decidua especially the leading immune cell type natural killer (NK) cell are critical …

[HTML][HTML] The human placenta shapes the phenotype of decidual macrophages

S Vondra, AL Höbler, AI Lackner, J Raffetseder… - Cell reports, 2023 - cell.com
During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the
decidua and communicate with maternal immune cells. The decidua distinguishes into …

[HTML][HTML] Transcriptomic drivers of differentiation, maturation, and polyploidy in human extravillous trophoblast

R Morey, O Farah, S Kallol, DF Requena… - Frontiers in Cell and …, 2021 - frontiersin.org
During pregnancy, conceptus-derived extravillous trophoblast (EVT) invades the
endomyometrium, anchors the placenta to the maternal uterus, and remodels the spiral …

Extravillous trophoblast migration and invasion: impact of environmental chemicals and pharmaceuticals

C Meakin, ES Barrett, LM Aleksunes - Reproductive Toxicology, 2022 - Elsevier
During pregnancy, the migration and invasion of extravillous trophoblasts (EVTs) into the
maternal uterus is essential for proper development of the placenta and fetus. During the first …

[HTML][HTML] (Dis) similarities between the decidual and tumor microenvironment

J Krstic, A Deutsch, J Fuchs, M Gauster… - Biomedicines, 2022 - mdpi.com
Placenta-specific trophoblast and tumor cells exhibit many common characteristics.
Trophoblast cells invade maternal tissues while being tolerated by the maternal immune …

[HTML][HTML] SARS-CoV-2 Transplacental transmission: a rare occurrence? an overview of the protective role of the placenta

YP Wong, GC Tan, TY Khong - International Journal of Molecular …, 2023 - mdpi.com
The outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by novel
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global …

[HTML][HTML] Revisiting steroidogenic pathways in the human placenta and primary human trophoblast cells

R Karahoda, S Kallol, M Groessl, E Ontsouka… - International journal of …, 2021 - mdpi.com
Steroid hormones play a crucial role in supporting a successful pregnancy and ensuring
proper fetal development. The placenta is one of the principal tissues in steroid production …

Ambient fine particulate matter exposures and human early placental inflammation

C Gong, M Chu, J Yang, X Gong, B Han, L Chen… - Environmental …, 2022 - Elsevier
The effect of fine particulate matter (PM 2.5) on human early maternal–fetal interface is
unknown. We explored the association between maternal exposure to ambient PM 2.5 and …

[HTML][HTML] Establishment of the fetal-maternal interface: Developmental events in human implantation and placentation

CC Huang, YW Hsueh, CW Chang, HC Hsu… - Frontiers in Cell and …, 2023 - frontiersin.org
Early pregnancy is a complex and well-orchestrated differentiation process that involves all
the cellular elements of the fetal-maternal interface. Aberrant trophoblast-decidual …

[HTML][HTML] Human placental endothelial cell and trophoblast heterogeneity and differentiation revealed by single-cell RNA sequencing

H Li, H Peng, W Hong, Y Wei, H Tian, X Huang, L Jia… - Cells, 2022 - mdpi.com
Background: The placenta is an important organ for fetal and maternal health during
pregnancy and impacts offspring health late in life. Defects in placental vasculature and …