The tumor necrosis factor receptor family member 4‐1BB plays a key role in the survival of
activated and memory CD8+ T cells. Depending on the disease model, 4‐1BB can …

Recent evidence shows that many molecules of the TNF family serve as counter-receptors,
inducing costimulation through reverse signals in addition to delivering signals through their …

TNF-related ligands (with the exception of lymphotoxin-α) are synthesized as type II
transmembrane proteins, though many of them also have soluble forms. An increasing …

Fas ligand (FasL, CD95L, APO-1L, CD178, TNFSF6, APT1LG1) is the key death factor of
receptor-triggered programmed cell death in immune cells. FasL/Fas-dependent apoptosis …

The tumor necrosis factor (TNF) cytokine family and the TNF/nerve growth factor (NGF)
family of their cognate receptors together control numerous immune functions, as well as …

Effector lymphocytes, including NK and T cells, express FasL. Expression of Fas, the
receptor for FasL in tumor cells, renders them susceptible to NK and T cell-mediated killing …

The TNF family member Fas ligand (FasL) induces apoptosis in Fas-expressing cells and
serves as a key death factor in the immune system. It is involved in the termination of …

Background Fas ligand (FasL) is expressed by activated T cells and induces death in target
cells upon binding to Fas. Loss-of-function FAS or FASLG mutations cause autoimmune …

The tumor necrosis factor (TNF) superfamily (TNFSF) is a protein superfamily of type II
transmembrane proteins commonly containing the TNF homology domain. The superfamily …

Interactions between the TNF-family receptor Fas (CD95) and Fas Ligand (FasL, CD178)
can efficiently induce apoptosis and are critical for the maintenance of immunological self …