Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Perivascular spaces (PVS) and blood–brain barrier (BBB) disruption are two key features of
cerebral small vessel disease (cSVD) and neurodegenerative diseases that have been …

Aging can cause attenuation in the functioning of multiple organs, and blood-brain barrier
(BBB) breakdown could promote the occurrence of disorders of the central nervous system …

The blood–brain barrier (BBB) plays important roles in the maintenance of brain
homeostasis. Its main role includes three kinds of functions:(1) to protect the central nervous …

Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal
transduction. Under stressful conditions, it can be generated from de novo synthesis …

Background Malignant glioma is among the most lethal and frequently occurring brain
tumors, and the average survival period is 15 months. Existing chemotherapy has low …

Transforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in
synaptic formation, plasticity, and neurovascular unit regulation. This review highlights TGF …

Stroke is an important disease with unmet clinical need. To uncover novel paths for
treatment, it is of critical importance to develop relevant laboratory models that may help to …

Subarachnoid hemorrhage (SAH) is a severe acute neurological disorder with a high fatality
rate. Early brain injury (EBI) and cerebral vasospasm are two critical complications of SAH …

This study aims to investigate the disrupted topological organization of gray matter (GM)
structural networks in cerebral small vessel disease (CSVD) patients with cerebral …