Skin barrier function and the microbiome

HJ Lee, M Kim - International journal of molecular sciences, 2022 - mdpi.com
Human skin is the largest organ and serves as the first line of defense against environmental
factors. The human microbiota is defined as the total microbial community that coexists in the …

The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment

P Facheris, J Jeffery, E Del Duca… - Cellular & Molecular …, 2023 - nature.com
Atopic dermatitis (AD) is the most common inflammatory skin disease, and it is considered a
complex and heterogeneous condition. Different phenotypes of AD, defined according to the …

[HTML][HTML] Role of Microbiome, Infection, and Inflammation in Autoimmune Diseases

N Amini, M Azimzadeh, MD Dosar, AM Fard… - Kindle, 2023 - preferpub.org
Microorganisms found in the human gastrointestinal tract (GIT) are symbiotic under steady
state conditions and have role in the homeostasis of the human host. The term microbiome …

[HTML][HTML] Tralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitis: analysis of …

LA Beck, T Bieber, S Weidinger, M Tauber… - Journal of the American …, 2023 - Elsevier
Background Atopic dermatitis (AD) is characterized by microbial dysbiosis, immune
dysregulation, and an impaired skin barrier. Microbial dysbiosis in AD involves a reduction …

A journey on the skin microbiome: pitfalls and opportunities

D Pistone, G Meroni, S Panelli, E D'Auria… - International journal of …, 2021 - mdpi.com
The human skin microbiota is essential for maintaining homeostasis and ensuring barrier
functions. Over the years, the characterization of its composition and taxonomic diversity has …

Immunomodulatory properties of host defence peptides in skin wound healing

M Petkovic, MV Mouritzen, B Mojsoska, H Jenssen - Biomolecules, 2021 - mdpi.com
Cutaneous wound healing is a vital biological process that aids skin regeneration upon
injury. Wound healing failure results from persistent inflammatory conditions observed in …

Accurate diagnosis of atopic dermatitis by combining transcriptome and microbiota data with supervised machine learning

Z Jiang, J Li, N Kong, JH Kim, BS Kim, MJ Lee… - Scientific reports, 2022 - nature.com
Atopic dermatitis (AD) is a common skin disease in childhood whose diagnosis requires
expertise in dermatology. Recent studies have indicated that host genes–microbial …

How our microbiome influences the pathogenesis of alopecia areata

P Sánchez-Pellicer, L Navarro-Moratalla… - Genes, 2022 - mdpi.com
Alopecia areata is a multifactorial autoimmune-based disease with a complex pathogenesis.
As in all autoimmune diseases, genetic predisposition is key. The collapse of the immune …

Interplay between skin microbiota dysbiosis and the host immune system in psoriasis: Potential pathogenesis

X Liang, C Ou, J Zhuang, J Li, F Zhang… - Frontiers in …, 2021 - frontiersin.org
Psoriasis is a multifactorial immune-mediated disease. The highly effective and eligible
treatment for psoriasis is limited, for its specific pathogenesis is incompletely elucidated …

The role of the skin microbiome in atopic dermatitis–correlations and consequences

R Fölster‐Holst - JDDG: Journal der Deutschen …, 2022 - Wiley Online Library
The physical barrier function of the skin is significantly supported by the (epi‐) dermal
immune system and the skin's own microbiome. Atopic dermatitis is characterized by an …