Plant callus: mechanisms of induction and repression
Plants develop unorganized cell masses like callus and tumors in response to various biotic
and abiotic stimuli. Since the historical discovery that the combination of two growth …
and abiotic stimuli. Since the historical discovery that the combination of two growth …
[HTML][HTML] Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
L Morera, M Lübbert, M Jung - Clinical epigenetics, 2016 - Springer
The term epigenetics is defined as heritable changes in gene expression that are not due to
alterations of the DNA sequence. In the last years, it has become more and more evident …
alterations of the DNA sequence. In the last years, it has become more and more evident …
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos
Histone modifications have critical roles in regulating the expression of developmental
genes during embryo development in mammals,. However, genome-wide analyses of …
genes during embryo development in mammals,. However, genome-wide analyses of …
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
KH Kim, W Kim, TP Howard, F Vazquez, A Tsherniak… - Nature medicine, 2015 - nature.com
Human cancer genome sequencing has recently revealed that genes that encode subunits
of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety …
of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety …
Regulation of gene transcription by Polycomb proteins
S Aranda, G Mas, L Di Croce - Science advances, 2015 - science.org
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …
regulation during development. Recent studies suggest that Polycomb repressive …
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
[HTML][HTML] On having no head: cognition throughout biological systems
The central nervous system (CNS) underlies memory, perception, decision-making, and
behavior in numerous organisms. However, neural networks have no monopoly on the …
behavior in numerous organisms. However, neural networks have no monopoly on the …
[HTML][HTML] Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
KL Yap, S Li, AM Muñoz-Cabello, S Raguz, L Zeng… - Molecular cell, 2010 - cell.com
Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell
growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the …
growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the …
[HTML][HTML] Genome-wide identification of polycomb-associated RNAs by RIP-seq
Polycomb proteins play essential roles in stem cell renewal and human disease. Recent
studies of HOX genes and X inactivation have provided evidence for RNA cofactors in …
studies of HOX genes and X inactivation have provided evidence for RNA cofactors in …