Emerging role and therapeutic implications of p53 in intervertebral disc degeneration

Y Wang, S Hu, W Zhang, B Zhang, Z Yang - Cell Death Discovery, 2023 - nature.com
Lower back pain (LBP) is a common degenerative musculoskeletal disease that imposes a
huge economic burden on both individuals and society. With the aggravation of social aging …

Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

H Ruan, Q Zhang, Y Zhang, S Li, X Ran - Critical Care, 2024 - Springer
Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory
response triggered by infection, involving multifactorial and intricate molecular mechanisms …

Chicoric acid ameliorates sepsis-induced cardiomyopathy via regulating macrophage metabolism reprogramming

HJ Sun, GL Zheng, ZC Wang, Y Liu, N Bao, PX Xiao… - Phytomedicine, 2024 - Elsevier
Background Sepsis-related cardiac dysfunction is believed to be a primary cause of high
morbidity and mortality. Metabolic reprogramming is closely linked to NLRP3 inflammasome …

Eriocitrin prevents Sepsis-induced acute kidney injury through anti-inflammation and anti-oxidation via modulating Nrf2/DRP1/OPA1 signaling pathway

M Wu, Z Huang, PDP Akuetteh, Y Huang… - Biochimica et Biophysica …, 2024 - Elsevier
Background Severe inflammation and oxidative stress are characteristics of sepsis-
associated kidney injury with high morbidity and mortality. Eriocitrin (ERI) has shown …

Synthesis and anti-inflammatory activities of two new N-acetyl glucosamine derivatives

Z Zhang, W Wang, P Xu, Q Cui, X Yang, AE Hassan - Scientific Reports, 2024 - nature.com
N-acetyl glucosamine (NAG) is a natural amino sugar found in various human tissues with
previously described anti-inflammatory effects. Various chemical modifications of NAG have …

Protective effect of zerumbone on sepsis-induced acute lung injury through anti-inflammatory and antioxidative activity via NF-κB pathway inhibition and HO-1 …

J Chen, L Zhou, X Li, X Wu, Y Li, L Si… - … Archives of Pharmacology, 2024 - Springer
Sepsis is a systemic illness for which there are no effective preventive or therapeutic
therapies. Zerumbone, a natural molecule, has anti-oxidative and anti-inflammatory …

Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice

Y Zhou, Z Du, Q Wu, M Guo, Z Chen, C Sun, X Li… - European Journal of …, 2024 - Elsevier
The modification based on natural products is a practical way to find anti-inflammatory
drugs. In this study, 26 osthole derivatives were synthesized, and their anti-inflammatory …

Dimethyl ester of bilirubin ameliorates Naja naja snake venom-induced lung toxicity in mice via inhibiting NLRP3 inflammasome and MAPKs activation

MB Nandana, M Bharatha, R Praveen, S Nayaka… - Toxicon, 2024 - Elsevier
Naja naja snake bite causes thousands of deaths worldwide in a year. N. naja envenomed
victims exhibit both local and systemic reactions that potentially lead to death. In clinical …

Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways

M Zhou, L Meng, Q He, C Ren, C Li - Frontiers in Pharmacology, 2024 - frontiersin.org
Background: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a
common respiratory disease characterized by persistent hypoxemia and an uncontrolled …

[HTML][HTML] Integrated HS-GC–IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of …

H Wang, P Wang, F Wang, H Chen, L Chen… - Current Research in …, 2024 - Elsevier
Citrus is an important genus in the Rutaceae family, and citrus peels can be used in both
food and herbal medicine. However, the bulk of citrus peels are discarded as waste by the …