RING finger domain and RING finger-like ubiquitin ligases (E3s), such as U-box proteins,
constitute the vast majority of known E3s. RING-type E3s function together with ubiquitin …

Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …

The AAA+ superfamily of ATPases, which contain a homologous ATPase module, are found
in all kingdoms of living organisms where they participate in diverse cellular processes …

Translocation of proteins across membranes of the endoplasmic reticulum, mitochondrion,
and chloroplast has been shown to be mediated by targeting signals present in the …

As a rule, organelles in eukaryotic cells can derive only from pre-existing organelles.
Peroxisomes are unique because they acquire their lipids and membrane proteins from the …

AAA proteins have entered the molecular realm after being known primarily for their wide
range of different functions. Structural studies have highlighted the organization of their …

Arthrobotrys oligospora (A. oligospora) is a typical nematode-trapping (NT) fungus that can
capture nematodes by producing adhesive networks. Peroxisomes are single membrane …

▪ Abstract Fifteen years ago, we had a model of peroxisome biogenesis that involved growth
and division of preexisting peroxisomes. Today, thanks to genetically tractable model …

Peroxisomes transport folded and oligomeric proteins across their membrane. Two cytosolic
import receptors, Pex5p and Pex7p, along with approximately 12 membrane-bound …

Peroxisomal import receptors bind their cargo proteins in the cytosol and target them to
docking and translocation machinery at the peroxisomal membrane (reviewed in ref.). The …