Glioblastoma (GBM), an aggressive high-grade glial tumor, is resistant to therapy and has a
poor prognosis due to its universal recurrence rate. GBM cells interact with the non-cellular …

Simple Summary The new trends in the research on glioblastomas (GBMs) are focusing on
understanding the crosstalk between proper neoplastic tissue and its microenvironment …

Glioma stem-like cells (GSCs) are regarded as the sources of oncogenesis, recurrence,
invasion and chemoresistance in malignant gliomas. Growing evidence suggests that the …

Abstract Guanylate-binding protein 2 (GBP2) is an interferon-inducible large GTPase which
is crucial to the protective immunity against microorganisms. However, its biological function …

Malignant brain tumors are difficult to manage clinically and are associated with high rates of
morbidity and mortality. Late diagnosis and the limitations of conventional therapies that may …

The extracellular matrix (ECM) plays a critical role during the development and invasion of
primary brain tumours. However, the function of ECM components and signalling between a …

Many varieties of new, complex diseases are constantly being discovered, which leaves
scientists with little choice but to embrace innovative methods for controlling the invasion of …

Glioblastomas are characterized by an intense local invasiveness that limits surgical
resection. One mechanism by which glioma cells enforce their migration into brain tissue is …

Despite the intensive recent research in cancer therapy, the prognosis in patients affected by
high-grade gliomas is still very unfavorable. The efficacy of classical anti-cancer strategies is …

The identification of angiogenesis-related proteins is important for the development of new
antiangiogenic therapies, and such proteins are potential new biomarkers for gliomas. The …