The proteasome is a large multi-subunit protease responsible for the degradation and
removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays …

Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

Lipid homeostasis is essential for normal cellular functions and dysregulation of lipid
metabolism is highly correlated with human diseases including neurodegenerative …

Abstract Development of colorectal cancer (CRC) involves activation of Kirsten rat sarcoma
viral oncogene homolog (KRAS) signaling. However, the post-transcriptional regulation of …

Biomolecular condensates are dynamic non-membrane-bound macromolecular high-order
assemblies that participate in a growing list of cellular processes, such as transcription, the …

The NLRP3 inflammasome is a key regulator of inflammation that responds to a broad range
of stimuli. The exact mechanism of activation has not been determined, but there is a …

Understanding the normal function of the Huntingtin (HTT) protein is of significance in the
design and implementation of therapeutic strategies for Huntington's disease (HD) …

The ubiquitin proteasome system (UPS) utilizes an orchestrated enzymatic cascade of E1,
E2, and E3 ligases to add single or multiple ubiquitin-like molecules as post-translational …

Small ubiquitin-related modifiers (SUMOs) function as post-translational protein
modifications and regulate nearly every aspect of cellular function. While a single ubiquitin …

Most proteins maintain protein homeostasis via post‑translational modifications, including
the ubiquitin‑proteasome system. Deubiquitinating enzymes (DUBs) have essential …