Background: Accumulating evidence indicates that miRNAs play an important role in the
development of amyotrophic lateral sclerosis (ALS). Most of previous studies on miRNA …

Amyotrophic lateral sclerosis is a degenerative disease affecting the motor neurons. In spite
of our growing insights into its biology, it remains a lethal condition. The identification of the …

Introduction: Several studies indicate the role of mesenchymal stem cells (MSCs) as an
important tool in regenerative medicine associated with injuries that affect the central …

Mutations in angiogenin (ANG), a member of the ribonuclease A superfamily, are associated
with amyotrophic lateral sclerosis (ALS; sporadic and familial) and Parkinson's disease. We …

Mutations in the MATR3 gene have been identified as a cause of familial amyotrophic lateral
sclerosis, but involvement of the matrin 3 (MATR3) protein in sporadic amyotrophic lateral …

Alternative splicing is a fundamental mechanism of eukaryotic RNA regulation that increases
the transcriptomic and proteomic complexity within an organism. Moreover, alternative …

Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a
multifunctional protein involved in the biogenesis and activity of several types of RNAs, and …

Inclusions of Tar DNA-binding protein 43 (TDP-43) are a pathological hallmark of
amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 …

Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS).
Missense mutations in a number of genes involved in RNA function and metabolisms are …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the
death of motor neurons. While the exact molecular and cellular basis for motor neuron death …