Mobile genetic elements are key to the evolution of bacteria and traits that affect host and
ecosystem health. Here, we use a framework of a hierarchical and modular system that …

The evidence that most adult-onset common diseases have a polygenic genetic architecture
fully consistent with robust biological systems supported by multiple back-up mechanisms is …

Abstract Design of de novo synthetic regulatory DNA is a promising avenue to control gene
expression in biotechnology and medicine. Using mutagenesis typically requires screening …

Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and
provide a scaffold for the integrative analysis of omics data. Researchers have developed …

Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Plant secondary metabolites (PSM s) are ubiquitous in plants and play many ecological
roles. Each compound can vary in presence and/or quantity, and the composition of the …

Auxin regulates numerous plant developmental processes by controlling gene expression
via a family of functionally distinct DNA-binding auxin response factors (ARFs), yet the …

Evolvability—the capacity to generate beneficial heritable variation—is a central property of
biological systems. However, its origins and modulation by environmental factors have not …

Evolutionary biology provides a crucial foundation for medicine and behavioral science that
has been missing from psychiatry. Its absence helps to explain slow progress; its advent …