Aberrant activation of the Wnt pathway is implicated in driving the formation of various
human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway …

Nitric oxide (NO) is a pleiotrophic regulator, pivotal to numerous biological processes,
including vasodilation, neurotransmission, and macrophage-mediated immunity. The highly …

The molecular messenger nitric oxide (NO) is synthesized endogenously from l-arginine by
three isoforms of the enzyme NO synthase. The isoform most consistently associated with …

The insulin resistance-colon cancer hypothesis, stating that insulin resistance may be
associated with the development of colorectal cancer, represents a significant advance in …

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …

Nitroglycerine has been used clinically in the treatment of angina for 130 years, yet
important details on the mechanism of action, biotransformation, and the associated …

NSAIDs, including those that are selective for cyclooxygenase‐2, are among the most widely
used drugs. However, these drugs produce significant side effects in the gastrointestinal and …

The novel nitric oxide (NO)-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs),
which are safer than their NSAID counterparts, inhibit the growth of colon cancer cells with …

Dysregulation of the Wnt pathway and altered β-catenin expression are central early events
in colorectal carcinogenesis. We studied the ortho, meta, and para (o-, m-, and p-) positional …

Nitric oxide (NO)-releasing aspirin (ASA), consisting of a traditional ASA molecule to which a
NO-donating moiety is covalently bound, is a promising colon cancer chemopreventive …