Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and
anti-oxidant effects. These are thought to be responsible for the potential effects of statins on …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Background: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia
and has minimal risk for extrapyramidal symptoms. Therapeutic benefits, however, are …

Metabolic abnormalities are serious health problems in individuals with schizophrenia.
Paradoxically, studies have noted an association where individuals who gained body weight …

Increases in serum triglyceride (TG) levels are associated with clinical response to clozapine
treatment. Clozapine is the most efficacious therapy for treatment of refractory schizophrenia …

Clozapine remains the drug of choice for resistant schizophrenia. However, its dose-
response relationship is still controversial. The current investigation aimed to develop a …

Background Metabolic side effects of antipsychotics contribute to morbidity and non-
compliance in treatment of psychosis. Multiple studies suggest that metabolic side effects …

The available data suggest that abnormalities of arachidonic acid-related signaling may be
of relevance in attenuated niacin-induced flush responses and lipid and glucose metabolism …

Background Verbal memory impairment is a core feature in schizophrenia even at early
stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the …

There is a long-term discussion in the literature concerning the possible link between the
improved efficacy of clozapine treatment and elevated plasma triglyceride levels, but no …