Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding …

The brain is critically dependent on a continuous supply of blood to function. Therefore, the
cerebral vasculature is endowed with neurovascular control mechanisms that assure that …

Neural activity is intimately tied to blood flow in the brain. This coupling is specific enough in
space and time that modern imaging methods use local hemodynamics as a measure of …

Recovery of function after a stroke is attributable to several factors, including events in the
first few days (eg, reabsorption of perilesional oedema, tissue reperfusion). However …

Ageing is the primary risk factor for cognitive deterioration. Given that the cerebral blood flow
(CBF) or regulation of cerebral circulation is attenuated in the elderly, it could be expected …

Ischemic stroke is one of the most disabling diseases and a leading cause of death globally.
Despite advances in medical care, the global burden of stroke continues to grow, as no …

The relationship between neurophysiological and cerebrovascular–metabolic findings in
patients affected by severe cerebrovascular deficits was investigated by comparing …

Exercise represents a behavioral intervention that enhances brain health and motor
function. The increase in cerebral blood volume in response to physical activity may be …

Functional MRI is based on the vascular response due to neuronal activation. The
underlying mechanism of fMRI is the blood oxygenation level-dependent (BOLD) effect—a …

Background and objective Cerebral blood flow (CBF), or perfusion, is a prerequisite for
maintaining brain metabolism and normal physiological functions. Diagnosing and …