DNA vaccines: are they still just a powerful tool for the future?

J Běláková, M Horynová, M Křupka, E Weigl… - Archivum immunologiae …, 2007 - Springer
Vaccination is historically one of the most successful strategies for the prevention of
infectious diseases. For safety reasons, modern vaccinology tends toward the usage of …

West Nile virus vaccines

RA Hall, AA Khromykh - Expert opinion on biological therapy, 2004 - Taylor & Francis
West Nile virus (WNV) is a mosquito-borne flavivirus that is emerging as a global pathogen.
In the last decade, virulent strains of the virus have been associated with significant …

[HTML][HTML] Immunological analysis of a Lactococcus lactis-based DNA vaccine expressing HIV gp120

GJ Gram, A Fomsgaard, M Thorn, SM Madsen… - Genetic Vaccines and …, 2007 - Springer
For reasons of efficiency Escherichia coli is used today as the microbial factory for
production of plasmid DNA vaccines. To avoid hazardous antibiotic resistance genes and …

Efficacy of DNA vaccines against infectious bursal disease virus in chickens enhanced by coadministration with CpG oligodeoxynucleotide

X Wang, P Jiang, S Deen, J Wu, X Liu… - Avian diseases, 2003 - meridian.allenpress.com
The objective of the present study was to investigate the feasibility of a DNA vaccine and
CpG oligodeoxynucleotide (ODN) to protect chickens against infectious bursal disease virus …

Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus in chickens adjuvanted with CpG …

MS Mahmood, M Siddique, I Hussain, A Khan… - Vaccine, 2006 - Elsevier
In the present study the efficacy of recombinant plasmids DNA vaccine encoding VP2 gene
of very virulent strain of infectious bursal disease virus (vvIBDV) isolated from Pakistan was …

Adjuvants for vaccines, a quest

F Audibert - International immunopharmacology, 2003 - Elsevier
Efficient vaccines comprise a specific moiety: the structures presenting the protective
antigenic determinants, and a nonspecific moiety: the adjuvant components. Dramatic …

Vaccination with DNA encoding cysteine proteinase confers protective immune response to rats infected with Clonorchis sinensis

JS Lee, IS Kim, WM Sohn, J Lee, TS Yong - Vaccine, 2006 - Elsevier
Cysteine proteinases of C. sinensis are important virulence factors that induce pathological
changes associated with larval migration and localized biliary epithelial destruction. This …

DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against “nonimmune” toxic renal injury

G Zheng, Y Wang, SH Xiang, YC Tay… - Journal of the …, 2006 - journals.lww.com
CC-chemokine-encoding DNA vaccine has been reported to be capable of inducing
immunologic memory to corresponding pathogenic self CC-chemokines in animal models of …

Enhancing DNA vaccination by sequential injection of lymph nodes with plasmid vectors and peptides

KA Smith, VL Tam, RM Wong, RR Pagarigan… - Vaccine, 2009 - Elsevier
DNA vaccines or peptides are capable of inducing specific immunity; however, their
translation to the clinic has generally been problematic, primarily due to the reduced …

Effect of miR-155 as a molecular adjuvant of DNA vaccine against VHSV in olive flounder (Paralichthys olivaceus)

HJ Lim, N Abdellaoui, KH Kim - Fish & Shellfish Immunology, 2019 - Elsevier
Rhabdoviral G protein-based DNA vaccines have been recognized as a useful way to
protect cultured fish from rhabdoviral diseases. In Korea, viral hemorrhagic septicemia virus …