The role of cardiolipin in cardiovascular health

Z Shen, C Ye, K McCain… - BioMed research …, 2015 - Wiley Online Library
Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both
mitochondrial function and cellular processes outside of the mitochondria. The importance of …

Detection of lipid and amphiphilic biomarkers for disease diagnostics

JZ Kubicek-Sutherland, DM Vu, HM Mendez, S Jakhar… - Biosensors, 2017 - mdpi.com
Rapid diagnosis is crucial to effectively treating any disease. Biological markers, or
biomarkers, have been widely used to diagnose a variety of infectious and non-infectious …

Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases

MR de Vries, MM Ewing, RCM de Jong… - Journal of Internal …, 2021 - Wiley Online Library
Background Phosphorylcholine (PC) is an important pro‐inflammatory damage‐associated
molecular pattern. Previous data have shown that natural IgM anti‐PC protects against …

Antibodies against malondialdehyde among 60-year-olds: prediction of cardiovascular disease

SK Samal, K Leander, M Vikström, L Griesbaum… - Scientific Reports, 2023 - nature.com
Malondialdehyde (MDA) is generated in oxidized LDL. It forms covalent protein adducts, and
is recognized by antibodies (anti-MDA). We previously studied IgM anti-MDA, and here we …

Human IgM Antibodies to Malondialdehyde Conjugated With Albumin Are Negatively Associated With Cardiovascular Disease Among 60‐Year‐Olds

D Thiagarajan, AG Frostegård, S Singh… - Journal of the …, 2016 - Am Heart Assoc
Background Malondialdehyde (MDA) is generated during lipid peroxidation as in oxidized
low‐density lipoprotein, but antibodies against oxidized low‐density lipoprotein show …

High levels of AGE-LDL, and of IgG antibodies reacting with MDA-lysine epitopes expressed by oxLDL and MDA-LDL in circulating immune complexes predict …

MF Lopes-Virella, KJ Hunt, NL Baker, G Virella… - Journal of Diabetes and …, 2016 - Elsevier
Background Circulating immune complexes (IC) containing modified forms of LDL (mLDL)
are strongly pro-inflammatory and when present in high levels are associated with the …

Phosphorylcholine monoclonal antibody therapy decreases intraplaque angiogenesis and intraplaque hemorrhage in murine vein grafts

F Baganha, TJ Sluiter, RCM de Jong… - International Journal of …, 2022 - mdpi.com
Phosphorylcholine (PC) is one of the main oxLDL epitopes playing a central role in
atherosclerosis, due to its atherogenic and proinflammatory effects. PC can be cleared by …

IgM antibodies to oxidized phosphatidylserine as protection markers in cardiovascular disease among 60-year olds

J Frostegård, J Su, S Sing, X Hua, M Vikström… - Plos one, 2017 - journals.plos.org
Objective Phosphatidylserine is exposed on apoptotic cells and is prone to oxidation
(OxPS). Here we analyze the association of IgM antibodies against OxPS (anti-OxPS) with …

[PDF][PDF] PCmAb decreases Intraplaque Angiogenesis and Intraplaque Hemorrhage

F Baganha, RCM de Jong, LA van Alst, EA Peters… - scholarlypublications …
Background: Phosphorylcholine (PC) is one of the main oxLDL epitopes and plays a central
role in atherosclerosis, in particular with its atherogenic and proinflammatory effects. PC can …

[PDF][PDF] Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases

W Jukema, K Pettersson, PHA Quax - scholarlypublications …
Phosphorylcholine (PC) is an important pro-inflammatory damage associated molecular
pattern. Previous data has shown that natural IgM anti-PC protect against cardiovascular …