Inhibitors of sars-cov-2 plpro
The emergence of SARS-CoV-2 causing the COVID-19 pandemic, has highlighted how a
combination of urgency, collaboration and building on existing research can enable rapid …
combination of urgency, collaboration and building on existing research can enable rapid …
Targeting SARS-CoV-2 papain-like protease in the postvaccine era
While vaccines remain at the forefront of global healthcare responses, pioneering
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …
Discovery of novel papain-like protease inhibitors for potential treatment of COVID-19
F Hersi, A Sebastian, H Tarazi, V Srinivasulu… - European Journal of …, 2023 - Elsevier
The recent emergence of different SARS-CoV-2 variants creates an urgent need to develop
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …
more effective therapeutic agents to prevent COVID-19 outbreaks. Among SARS-CoV-2 …
Systematic exploration of SARS-CoV-2 adaptation to Vero E6, Vero E6/TMPRSS2, and Calu-3 cells
P Aiewsakun, W Phumiphanjarphak… - Genome Biology and …, 2023 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread
globally, and scientists around the world are currently studying the virus intensively in order …
globally, and scientists around the world are currently studying the virus intensively in order …
Structure-based design of SARS-CoV-2 papain-like protease inhibitors
The COVID-19 pandemic is caused by SARS-CoV-2, an RNA virus with high transmissibility
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads
We report here the synthesis and biological evaluation of a series of small molecule SARS-
CoV-2 PLpro inhibitors. We compared the activity of selected compounds in both SARS-CoV …
CoV-2 PLpro inhibitors. We compared the activity of selected compounds in both SARS-CoV …
Antiviral and possible prophylactic significance of myricetin for COVID-19
PK Agrawal, C Agrawal… - Natural Product …, 2023 - journals.sagepub.com
Myricetin (3, 5, 7, 3′, 4′, 5′-hexahydroxyflavone), a common dietary flavonoid, has been
reported for its roles in improving health due to various pharmacological activities, such as …
reported for its roles in improving health due to various pharmacological activities, such as …
Repurposing 1, 2, 4-oxadiazoles as SARS-CoV-2 PLpro inhibitors and investigation of their possible viral entry blockade potential
MS Ayoup, MM ElShafey, H Abdel-Hamid… - European Journal of …, 2023 - Elsevier
Although vaccines are obviously mitigating the COVID-19 pandemic diffusion, efficient
complementary antiviral agents are urgently needed to combat SARS-CoV-2. The viral …
complementary antiviral agents are urgently needed to combat SARS-CoV-2. The viral …
Development of Fluorescence-Based Assays for Key Viral Proteins in the SARS-CoV-2 Infection Process and Lifecycle
M Deng, C Zhang, W Yan, L Chen, B He… - International Journal of …, 2024 - mdpi.com
Since the appearance of SARS-CoV-2 in 2019, the ensuing COVID-19 (Corona Virus
Disease 2019) pandemic has posed a significant threat to the global public health system …
Disease 2019) pandemic has posed a significant threat to the global public health system …
Development of 2-chloroquinoline based heterocyclic frameworks as dual inhibitors of SARS-CoV-2 MPro and PLPro
Evolution of new variants of SARS-CoV-2 warrant the need for the continued efforts in
identifying target-oriented new drugs. Dual targeting agents against M Pro and PL Pro not …
identifying target-oriented new drugs. Dual targeting agents against M Pro and PL Pro not …