Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects

C Johannessen Landmark… - Expert opinion on …, 2020 - Taylor & Francis
ABSTRACT Introduction: Antiepileptic drugs (AEDs) are the cornerstone of treatment of
patients with epilepsy, and there are presently 27 licensed AEDs making AEDs among the …

Eslicarbazepine acetate: a new improvement on a classic drug family for the treatment of partial-onset seizures

GL Galiana, AC Gauthier, RH Mattson - Drugs in R&D, 2017 - Springer
Eslicarbazepine acetate is a new anti-epileptic drug belonging to the dibenzazepine
carboxamide family that is currently approved as adjunctive therapy and monotherapy for …

Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines

A Reimers, JA Berg, ML Burns, E Brodtkorb… - Drug design …, 2018 - Taylor & Francis
Background and objective Laboratories sometimes use different reference ranges for the
same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may …

Effect and tolerability of perampanel in patients with drug-resistant epilepsy

IMB Lossius, T Svendsen, HF Sødal, K Kjeldstadli… - Epilepsy & Behavior, 2021 - Elsevier
Objective Perampanel is one of the most recently approved antiseizure medications. The
aim of the present study was to assess clinical efficacy and tolerability, in combination with …

Real-world analysis of retention on cenobamate in patients with epilepsy in the United States

S Stern, M Weingarten, S Mandapati, L Ferrari… - Epilepsy Research, 2023 - Elsevier
Background This retrospective, observational study used US claims data to assess retention
rates on cenobamate compared with four branded antiseizure medications (ASMs) in …

Efficacy, tolerability and pharmacokinetic variability of brivaracetam in adults with difficult-to-treat epilepsy

T Svendsen, E Brodtkorb, HL Linge, ML Burns… - Epilepsy Research, 2022 - Elsevier
Purpose Brivaracetam (BRV) is one of our latest antiseizure medications (ASMs). It is an
analogue of levetiracetam with limited real-life experience. The purpose of this study was to …

Pharmacokinetic considerations about antiseizure medications in the elderly

R Roberti, C Palleria, V Nesci, M Tallarico… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Epilepsy represents the third most common neurological disorder in the elderly.
Antiseizure medications (ASMs) are often used not only to treat epilepsy but also other …

Pharmacokinetic factors to consider in the selection of antiseizure drugs for older patients with epilepsy

GD Anderson, S Hakimian - Drugs & aging, 2018 - Springer
The incidence of epilepsy is highest in the older adult age group. Seizures in older adults
can be more difficult to diagnose because their presentation is often subtle and can easily …

Role of human arylacetamide deacetylase (AADAC) on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity

K Hirosawa, T Fukami, K Tashiro, Y Sakai, F Kisui… - Drug Metabolism and …, 2021 - ASPET
Human arylacetamide deacetylase (AADAC) plays a role in the detoxification or activation of
drugs and is sometimes involved in the incidence of toxicity by catalyzing hydrolysis …

Serum sodium levels and related treatment‐emergent adverse events during eslicarbazepine acetate use in adults with epilepsy

RT Wechsler, RA Radtke, M Smith, DG Vossler… - …, 2019 - Wiley Online Library
Objective To examine the frequency of hyponatremia and potentially related symptoms in
clinical trials of eslicarbazepine acetate (ESL) in adults with focal‐(partial‐) onset seizures …